Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Prehospital ARNI use, No prehospital ARNI use.
- Who it may be relevant to
- Registry conditions: Heart Failure. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Evaluating the Impact of Pre-Hospital Angiotensin Receptor-Neprilysin Inhibitor (ARNI) Therapy on Short-Term Clinical Outcomes in Heart Failure Patients With Reduced Ejection Fraction: A Comparative Study
Overview
This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine called angiotensin receptor-neprilysin inhibitor (ARNI) before hospital admission affects short-term health outcomes. The study will compare two groups of participants: those who were already taking ARNI before coming to the hospital and those who were not. Information will be collected from medical records during the hospital stay, including heart-related events, kidney-related events, and how long participants stay in the hospital. Some participants will also be followed for a short period after discharge. This study may help improve understanding of outcomes associated with ARNI use in people with heart failure in routine clinical care.
Interventions
- Other Prehospital ARNI use
Participants who were using ARNI therapy before hospital admission - Other No prehospital ARNI use
Participants who were not using ARNI therapy before hospital admission
Primary outcome measures
- In-hospital cardiac and renal events [Time frame: 3 months]
Secondary outcome measures (1)
- NYHA classification [Time frame: 3 months]
Eligibility criteria
Inclusion criteria
- >= 18 years, male or female EF <40%
Exclusion criteria
- EF>40% Pregnancy or breastfeeding
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Mansoura university Hospital — Al Mansurah
Identifiers
NCT: NCT07347925 · REC-FPFUE-NO3/2025