Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Endovascular Therapy.
- Who it may be relevant to
- Registry conditions: Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Endovascular Versus Medical Therapy for Acute Large-Core Basilar Artery Occlusion: A Multicenter Retrospective Registry Study (BAOCHE-LC)
Overview
This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion. It also investigates clinical, imaging, and laboratory factors associated with functional outcomes and mortality. Patients are grouped according to the treatment received in routine clinical practice.
Interventions
- Procedure Endovascular Therapy
Endovascular therapy performed as part of routine clinical care for acute basilar artery occlusion, including mechanical thrombectomy with stent retriever and/or aspiration. Rescue angioplasty and/or intracranial stenting may be used at the operator's discretion. Peri-procedural management and concomitant medical therapy follow local standard practice.
Primary outcome measures
- Proportion of Patients Achieving mRS 0-3 at 90 Days [Time frame: 90 days]
Secondary outcome measures (4)
- Ordinal Shift analysis of mRS at 90 days [Time frame: 90 days]
- Rate of All-Cause Mortality at 90 Days [Time frame: 90 days]
- Rate of Symptomatic Intracranial Hemorrhage [Time frame: 24 (-2/+12) hours]
- Proportion of Patients Achieving mRS 0-3 at 1 year [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- Age ≥18 years, men or women.
- Occlusion (TIMI 0-1) of the basilar artery or intracranial segments of both vertebral arteries (V4) as evidenced by CTA/MRA/DSA.
- Time from symptom onset (or last known well) to treatment (endovascular therapy or medical therapy) ≤7 days.
- Patients with large core infarction in the posterior circulation, defined as a posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) score of 0-5 on CT angiography source images or MR with diffusion-weighted imaging or non-contrast CT.
Exclusion criteria
- Subjects with occlusions in both anterior and posterior circulation.
- CT or MR evidence of hemorrhage (the presence of microbleeds on MRI is allowed).
- Missing key clinical information (e.g., unavailable baseline NIHSS, unclear symptom onset/last known well time, or missing major treatment information including whether EVT was performed).
- Baseline NIHSS score <6.
- Woman of childbearing potential who is known to be pregnant or lactating or who has a positive pregnancy test on admission.
- Missing follow-up outcomes at 90 days.
- Any other condition judged by investigators to substantially affect analysis or interpretation.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Xuanwu Hospital — Beijing
Identifiers
NCT: NCT07345702 · BAOCHE-LC