Evaluation of a Neuropsychological Tool to Assess Temporal Processing Abilities in Alzheimer's Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Chronos battery.
- Who it may be relevant to
- Registry conditions: Alzheimer's Disease (AD), Time Perception. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Perceiving and representing the passage of time allows us to temporally organize perceptions and memories for the coordination of actions, planning, and the mobilization of cognitive processes toward a goal. This innovative project aims to clarify the profile of time impairment associated with normal aging and the progression of age-related pathologies. This project proposes to develop a new neuropsychological tool for quantifying and preventing changes in the relationship to time associated with Alzheimer's disease. Four aspects of time are distinguished, which are measured separately and distributed along a continuum between perception and memory: (a) perception of simultaneity and order; (b) processing of durations; (c) subjective sense of the passage of time; and (d) mental time travel. Crucially, many neurological and psychiatric disorders are associated with impairment in one or more aspects of time. However, time remains largely unexplored in clinical practice. Patients with Alzheimer's disease will complete the CHRONOS battery. This battery allows for a rapid assessment (approximately ten minutes) of the four aspects of time. This new battery will enable the identification of behavioral markers aimed at improving prognosis and prevention regarding individual cognitive trajectories of aging. The relationship to time is closely linked to each person's personal experience. This project will help to put into words difficulties that are not always expressed in terms of time. Thus, considering these pathologies from the perspective of time aims to better understand and prevent their difficulties and to guide the identification of new markers and new avenues for remediation.
Interventions
- Behavioral Chronos battery
Patients will perform the battery during a neuropsychological assessment
Primary outcome measures
- Behavioral difference at the battery assessing temporal processing (CHRONOS (Cognitive Health Ratings Of Neuropsychological Skills for temporal perception) Score /30 + subscores) [Time frame: From enrollment to the end of the neuropsychological assessment (three hours)]
Eligibility criteria
Inclusion criteria
- No objection from the participant or their legal representative, if applicable, prior to or during the assessment
- Deficit in at least two cognitive functions, including episodic memory.
Exclusion criteria
- History of head trauma with loss of consciousness lasting more than 1 hour
- Presence of clinically significant major psychiatric disorders (according to DSM-IV-TR criteria)
- Use of medications likely to alter cognitive and/or brain function (decision by the principal investigator)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
France · 1 center
- Caen Hospital, neurology Unit — Caen
Identifiers
NCT: NCT07341009 · 25-0136