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Recruiting NCT07340125

Pistachio Snacking and Metabolic Flexibility

No phase Interventional Overweight (BMI > 25) Obese But Otherwise Healthy Participants Overweight or Obese Obese Patients (BMI ≥ 30 kg/m²)

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Pistachio.
Who it may be relevant to
Registry conditions: Overweight (BMI > 25), Obese But Otherwise Healthy Participants, Overweight or Obese, Obese Patients (BMI ≥ 30 kg/m²). Basic parameters: 25 years — 45 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Effects of Pistachio Snacking on Metabolic Flexibility in Healthy Overweight and Obese Adults

Overview

The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.

Interventions

  • Other Pistachio
    Roasted, lightly salted, pistachio kernels (no shell)

Primary outcome measures

  • resting metabolism [Time frame: Day 0 and Day 5]
  • exercise metabolic flexibility [Time frame: Day 0 and Day 5]
  • post-exercise metabolism [Time frame: Day 0 and Day 5]
Secondary outcome measures (4)
  • Caloric Intake [Time frame: Day 0 and Day 4]
  • Carbohydrate Intake [Time frame: Day 0 and Day 4]
  • Protein Intake [Time frame: Day 0 and Day 4]
  • Fat Intake [Time frame: Day 0 and Day 4]

Eligibility criteria

Inclusion criteria

  • Males and Females
  • Age: 25-45 years
  • Overweight or obese (BMI=25.0-34.9 kg/m²)
  • Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)
  • Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)
  • Not meeting weekly physical activity recommendations (<150 min moderate-intensity exercise, <75 minutes of vigorous-intensity exercise, and <2 days of strength training)
  • Not following a diet that is restrictive or eliminates certain food group/types

Exclusion criteria

  • Allergies to nuts, especially tree nuts
  • Has a pacemaker
  • Following a diet that is restrictive or eliminates certain food group/types
  • Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer/cancer treatment (within the past year)
  • History of gastrointestinal surgery, hysterectomy
  • For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Crossover
Masking
Open label
Primary purpose
Treatment

Study locations

United States · 1 center
  • Public Health Research Center: Clinical Exercise Research Center — Columbia

Identifiers

NCT: NCT07340125 · Pro00145186

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗