Fertility Outcomes of Ovarian Tissue Cryopreservation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Ovarian tissue freezing and subsequent auto-transplantation after thawing.
- Who it may be relevant to
- Registry conditions: Neoplasms. Basic parameters: 0 years — 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
With the advancement of assisted reproductive technology, more young cancer patients can consider having children. Ovaries and testes are important reproductive organs, and drugs, diseases, chemotherapy, and radiotherapy can all damage them. Reproductive preservation technology aims to protect patients whose reproductive ability has been damaged due to gonadotoxic drug therapy. Women can preserve their reproductive ability by freezing ovarian tissue cryopreservation so that they can have children in the future. Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital will be invited to participate in the study. Here, we aim to evaluate the outcomes after ovarian tissue cryopreservation.
Interventions
- Other Ovarian tissue freezing and subsequent auto-transplantation after thawing
Removal of the ovarian tissue will be retrieved via laparoscopic surgery under general anesthesia. The ovarian cortical tissue obtained will be transferred on ice to the laboratory for cryopreservation. After medical treatment, if the patient would like to start a family but has experienced premature ovarian failure, she will have ovarian tissue auto-transplantation after thawing.
Primary outcome measures
- Surgical complications [Time frame: 15 years]
- Pregnancy rate [Time frame: 15 years]
Eligibility criteria
Inclusion criteria
- Patients aged from 0-18 years old and diagnosed with cancer
- Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital
- For patients under 18 years old, parents/legal guardians will be asked to further sign the consent for them.
Exclusion criteria
- Patients unable to provide consent/assent (i.e. significant psychiatric problems/cognitive delay)
- Male patients
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07339995 · PAED-2025-067