Fluid Balance in Acute Kidney Injury in Critically Ill Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Fluid Balance, Acute Kidney Injury, Critically Ill Acute Kidney Injury, Critically Ill. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Fluid Balance During Early Hours of Acute Kidney Injury in Critically Ill Patients
Overview
This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults. Patients without AKI at entry will have fluids tracked hourly via charts, weights, and labs to assess AKI risk by KDIGO criteria within 7 days. Findings may guide better fluid management to lower AKI rates.
Detailed description
This prospective observational cohort study at Assiut University Hospital ICU investigates the association between fluid balance in the first 48 hours of admission and acute kidney injury (AKI) development. Critically ill adults (≥18 years) without AKI at baseline will undergo routine monitoring: hourly fluid intake/output (IV fluids, blood products, urine, drains, insensible losses), daily weights, serial labs (SCr, BUN, electrolytes, albumin, CRP), and clinical/hemodynamic assessments. AKI is defined/staged by KDIGO criteria within 7 days. Sample size is 120 (Epi-Info calculated, 38.4% expected AKI incidence). Data analysis will examine if positive/negative balances predict AKI incidence, severity, RRT need, ICU stay, and 28-day mortality, using AKI-FB risk score. No interventions; standard care only.
Primary outcome measures
- Incidence of Acute Kidney Injury (AKI) [Time frame: Within 7 days after ICU admission]
Secondary outcome measures (1)
- AKI Stage by KDIGO Criteria [Time frame: Within 7 days after ICU admission]
Eligibility criteria
Inclusion criteria
- Adults aged 18 years or older admitted to the ICU.
- Patients with no AKI at ICU admission.
- AKI secondary to (prerenal cause-renal and post renal with manifestation of hypovolemia)-postoperative settings-On top of CKD up to Stage 111b-Compansated heart failure with indication of fluid therapy
Exclusion criteria
- Patients with pre-existing end-stage renal disease requiring dialysis.
- Patients with known chronic kidney disease stage 4 or higher.
- ICU readmissions during the same hospitalization.
- Patients who received renal replacement therapy before ICU admission
- Patients with AKI with manifestation of over load as pulmonary edema- pulmonary embolism-Acute decompensated heart failure
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07338734 · Fluid Balance in AKI