Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Lewy Body Disease. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Lewy body disease (LBD) is a neurodegenerative disorder that causes cognitive and behavioral problems. However, it is difficult to diagnose, and its pathophysiology is still not fully understood. The usual diagnostic criteria for LBD have excellent specificity but poor sensitivity. In particular, we lack paraclinical tests that can make a significant contribution. LBD patients may exhibit abnormalities in brain activity dynamics, which can be detected by EEG and may be linked to neuronal dysfunctions specific to the disease. The objective of this study is twofold: first, to assess the validity of this observation, that is, to confirm that the observed phenomenon is indeed linked to the pathophysiology of LBD, and second, to clarify the nature of these abnormalities by exploring the brain dynamics of LBD patients in greater detail.
Primary outcome measures
- Parameter θ of dynamic fluidity of brain activity [Time frame: Up to 12 months]
Eligibility criteria
Inclusion criteria
- Adult subjects (≥18 years old).
- Subject who participated in the Alpha-Lewy-MA cohort and underwent RT-QuIC analysis.
- Subject who underwent a standard EEG examination at HUS between January 1, 2012, and January 1, 2020.
Exclusion criteria
\- Subject who expressed opposition to participating in the study.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- Service de psychiatrie de la personne âgée - CHU de Strasbourg - France — Strasbourg
Identifiers
NCT: NCT07335692 · 9691