Study of Platelet Population Changes Under Circulatory Support With ECMO
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Cardiac Failure, Respiratory Failure. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Advances in flow cytometry techniques have led to a better understanding of platelet phenotypes and have revealed the existence of four major platelet populations with distinct functional properties (native, proaggregating, procoagulating, or apoptotic). These phenotypes have a significant impact on the hemostatic capacity of blood platelets, and a proportional change in these populations during ECMO treatment could, at least in part, contribute to the observed complications.
Primary outcome measures
- Proportional Changes in the Different Platelet Populations (native, proaggregating, procoagulant, or apoptotic) [Time frame: Days 1, 3, and 7 after the initiation of ECMO treatment.]
Eligibility criteria
Inclusion criteria
- Adult patient (≥18 years) treated in one of the intensive care units of the Anesthesia and Intensive Care Department at Strasbourg University Hospital.
- Implanted with veno-arterial or veno-venous ECMO within the previous 24 hours.
Exclusion criteria
- Subject who has expressed their opposition to participating in the study.
- Subject under legal protection.
- Subject under guardianship or curatorship.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- Service d'anesthésie-réanimation - CHU de Strasbourg - France — Strasbourg
Identifiers
NCT: NCT07334457 · 9614