Based on the Spatio-temporal Coding Characteristics of Frontotemporal Network, This Paper Explores the Mechanism of Five-tone Speech Training in Reshaping Language Fluency Function.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Traditional Chinese Medicine Five-Tone Therapy, Melodic Intonation Training, Standard speech therapy; Routine medical treatment; Health education.
- Who it may be relevant to
- Registry conditions: Aphasia. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
To explore the mechanism of five-tone speech training in reshaping language fluency function and the clinical efficacy of aphasia language function, daily communication ability and communication efficiency based on the temporal and spatial coding characteristics of frontotemporal network. Combined with EEG ( rsEEG, ERP ), nuclear magnetic resonance examination and near-infrared imaging system examination to explore its effect on brain electrophysiological activity. So as to promote the modernization of traditional Chinese medicine rehabilitation treatment technology and the popularization and application of speech rehabilitation treatment technology.
Interventions
- Other Traditional Chinese Medicine Five-Tone Therapy
Therapeutic Protocol for 'Five-Tone' Therapy Based on Melodic Intonation Training Model: Subjects undergo syndrome differentiation and treatment, with corresponding 'Five-Tone' melodies selected. Based on the melodic intonation training model, active training is conducted through melodic intervention measures. ① Rehabilitation training② Conventional Medical Management.③ Health Education: - Other Melodic Intonation Training
All eligible participants enrolled in the study received four weeks of melodic intonation therapy, administered once daily for 40 minutes, five days per week.① Rehabilitation training② Conventional Medical Management.③ Health Education: - Other Standard speech therapy; Routine medical treatment; Health education
① Rehabilitation training: Physicians conduct limb movement and speech rehabilitation training for participants in accordance with the Clinical Evidence-Based Practice Guidelines for Integrated Traditional and Western Medicine Rehabilitation of Stroke (2024 Edition). ② Conventional Medical Management: Standard foundational treatment is administered to enrolled subjects in accordance with the National Health Commission's Guidelines for the Prevention and Treatment of Cerebrovascular Diseases (202
Primary outcome measures
- Semantic Fluency Test [Time frame: Baseline and Week 4 post-intervention]
- Speech fluency test [Time frame: Baseline and Week 4 post-intervention]
Secondary outcome measures (4)
- Boston Diagnostic Aphasia Examination，BDAE [Time frame: Baseline and Week 4 post-intervention]
- Minimum Mental State Examination [Time frame: Baseline and Week 4 post-intervention]
- Western Aphasia Battery，WAB [Time frame: Baseline and Week 4 post-intervention]
- Chinese Functional Communication Profile, CFCP [Time frame: Baseline and Week 4 post-intervention]
Eligibility criteria
Eligibility Criteria
Inclusion criteria
Age between 18 and 70 years
Right-handed
Native Chinese speakers
Clinical diagnosis of post-stroke aphasia caused by ischemic stroke, confirmed by CT or MRI
Diagnosis of non-fluent aphasia based on the Western Aphasia Battery (WAB), with BDAE severity rating of 1-5
Time since stroke onset ≥ 2 weeks
Stable vital signs, clear consciousness, and no severe cognitive impairment
Ability to understand the study procedures and provide written informed consent (or consent provided by a legally authorized representative)
Exclusion criteria
History of aphasia or neurological disease not caused by stroke (e.g., traumatic brain injury, brain tumor, neurodegenerative diseases)
Severe visual or auditory impairments that would interfere with task performance
Severe cognitive impairment or disorders of consciousness preventing cooperation with language assessment or intervention
Severe dysarthria or apraxia of speech that precludes valid language assessment
History of epilepsy or other severe neurological conditions
Severe systemic diseases (e.g., severe cardiopulmonary dysfunction, renal failure, hepatic failure, malignancy)
Psychiatric disorders (e.g., schizophrenia, severe depression, or other major psychiatric illnesses)
Contraindications to MRI or fNIRS assessment (e.g., metallic implants, severe claustrophobia)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07329751 · Jia Huang