Comparing Tear Proteomics Profile in Dry Eye Disease pre-and Post-treatment With Low Level Light Therapy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Dry Eye, Meibomian Gland Dysfunction (Disorder). Basic parameters: from 21 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Singapore
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of this research study is to understand the mechanism of action of low level light therapy and also potentially yield markers associated with good treatment response. Low-level light therapy is light-based treatment delivered through advance eye-light device. This therapy uses light energy to provide energy to the meibomian gland cells to slow down age-ing, improve tear stability and reduce inflammation.
Primary outcome measures
- Comparing tear proteomics profile in dry eye disease pre-and post-treatment with low level light therapy [Time frame: Baseline visit and Post Baseline visit 3 months (+3 weeks).]
Eligibility criteria
Inclusion criteria
- Must be eligible for, and have consented for low level light therapy
- Must not have presented to the clinic for an acute eye problem such as visual loss or painful eye
- Ability to give informed consent.
- Age more or equals to 21 years old.
Exclusion criteria
- Patients who are unable to or decline to give consent.
- Age less than 21 years old.
- Patients who presented to the clinic for an acute eye problem such as visual loss or painful eye.
- Patients not suitable for low level lighttherapy:
- Pregnant
- Fitted with pacemakers, metal, electrical, acoustic prosthetics
- Epilepsy, cardiac rhythm or frequency disorders
- Fever, thrombophlebitis or acute phlebitis of the legs, large-sized varicose veins, or venous surgery within 2 months
- Uncontrolled hypertension or severe diabetes
- Open wounds on eyelid or skin
- Evolving cancer or hepatitis
- Blood anticoagulant or coagulation defect
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Singapore · 1 center
- Singapore Eye Research Insititute — Singapore
Identifiers
NCT: NCT07329712 · 2025-0870 · 2025-0870