Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: General anesthesia, External oblique and rectus abdominis plane (EXORA) block.
- Who it may be relevant to
- Registry conditions: Ultrasound, External Oblique, Rectus Abdominis Plane Block, Neuroendocrine Stress Response. Basic parameters: 21 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Effect of Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery: A Prospective Randomized Controlled Trial
Overview
This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.
Detailed description
Umbilical hernias of the abdomen are defined as a non-inguinal, non-hiatal defect in the fascia of the abdominal wall. Surgical stress response refers to the physiologic response to surgery and the hormonal and metabolic changes that follow it.
Fascial plane blocks are gaining attention for perioperative analgesia due to their efficacy and safety profiles. The external oblique and rectus abdominis plane (EXORA) block is an emerging technique that provides a sensory block to the anterolateral abdominal wall, potentially filling gaps left by other commonly used blocks, such as the quadratus lumborum (QLB) or erector spinae plane (ESP) blocks.
Interventions
- Other General anesthesia
Patients will receive general anesthesia only. - Other External oblique and rectus abdominis plane (EXORA) block
Patients will receive general anesthesia and an external oblique and rectus abdominis plane (EXORA) block with 0.25% bupivacaine.
Primary outcome measures
- Neuroendocrine stress response [Time frame: 24 hours postoperatively]
Secondary outcome measures (5)
- Serum cortisol level [Time frame: 24 hours postoperatively]
- Time of first rescue analgesia [Time frame: 24 hours postoperatively]
- Total intraoperative fentanyl consumption [Time frame: Intraoperatively]
- Total morphine consumption [Time frame: 24 hours postoperatively]
- Degree of pain [Time frame: 24 hours postoperatively]
Eligibility criteria
Inclusion criteria
- Aged from 21 to 65 years.
- Both sexes.
- American Society of Anesthesiologists (ASA) Physical status I and Ⅱ.
- Schedule for elective umbilical hernia surgery under general anesthesia.
Exclusion criteria
- ASA Ⅲ or Ⅳ.
- Patients with metabolic abnormalities, e.g., diabetes mellitus.
- Patients receiving corticosteroids.
- History of allergies to local anesthetics.
- Bleeding or coagulation disorders.
- Anatomical abnormalities.
- Psychiatric and neurological disorders.
- Complicated hernial defect (obstructed).
- Patient refusal.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Tanta University — Tanta
Identifiers
NCT: NCT07324863 · 36265MD474/10/25