Diagnostic Value of Transcranial Doppler Ultrasound for Evaluating Neonatal Craniocerebral Injuries
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Transcranial Doppler ultrasound.
- Who it may be relevant to
- Registry conditions: Diagnostic Value, Transcranial Doppler Ultrasound, Neonatal Craniocerebral Injuries. Basic parameters: up to 37 Weeks · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study aims to evaluate the diagnostic value of transcranial Doppler ultrasonography (TCD) for evaluating neonatal craniocerebral injuries.
Detailed description
A high-risk neonate refers to an infant, irrespective of gestational age or birth weight, who exhibits an elevated likelihood of experiencing health complications or death. Preterm infants, defined as those born alive at a gestational age of less than 37 weeks, have seen increased birth and survival rates due to advancements in medical technology and the widespread establishment of Neonatal Intensive Care Units (NICUs).
Neonatal sepsis is one of the leading causes of morbidity and mortality among term and preterm infants worldwide.
Transcranial Doppler ultrasonography (TCD) is the only noninvasive method that enables reliable evaluation of blood flow in the basal intracerebral vessels, providing physiological information complementary to anatomic imaging. TCD is relatively inexpensive, can be performed at the bedside, and enables monitoring in acute emergency settings and for prolonged periods with high temporal resolution, making it ideal for studying dynamic cerebrovascular responses.
Interventions
- Device Transcranial Doppler ultrasound
Trans-cranial ultrasound will be carried out for assessment of blood flow velocity in the anterior \[ACA\] and middle cerebral arteries \[MCA\] using duplex pulsed Doppler ultrasound.
Primary outcome measures
- Sensitivity of transcranial Doppler ultrasound [Time frame: 6 months post-procedure]
Eligibility criteria
Inclusion criteria
- Both sexes.
- High-risk neonates with any of the following:
- Critically ill neonates.
- Neonatal sepsis.
- Neonatal encephalopathy includes hypoxic-ischemic encephalopathy.
- Respiratory distress.
- Neonatal seizures.
- Birth asphyxia.
- Signs and or symptoms of central nervous system disorders like microcephaly, macrocephaly, hypotonia, unexplained poor feeding,
- Neonates born out of traumatic/instrumental labor.
- Suspected metabolic disturbances.
- Neonates with low APGAR score (<7).
- Neonates with low birth weight (<2.5 kg).
Exclusion criteria
- Congenital malformations.
- Genetic metabolic diseases or other severe complications.
- Severe intrauterine infection.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Kafrelsheikh University — Kafr ash Shaykh
Identifiers
NCT: NCT07322315 · KFSIRB200-842