Correlation Between Postoperative Blood Pressure Variability, Perfusion Index and Perioperative Adverse Events in Cardiac Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Blood Pressure Variability and Perfusion Index.
- Who it may be relevant to
- Registry conditions: Cardiac Surgery Intensive Care Treatment, Hemodynamics. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Correlation Between Postoperative Blood Pressure Variability, Perfusion Index and Perioperative Adverse Events in Cardiac Surgery: A Single-Center Prospective Observational Cohort Study
Overview
In patients after cardiac surgery, disturbances in macrocirculatory fluctuations and tissue perfusion commonly coexist. The stress state induced by factors such as surgical manipulation, cardiopulmonary bypass, anesthetic agents, pain, and ischemia-reperfusion injury, along with the use of vasoactive drugs postoperatively, often leads to increased blood pressure fluctuations in the early postoperative period. Additionally, dysregulation of organ blood flow autoregulation post-surgery contributes to peripheral circulatory impairment, rendering perfusion pressure an unreliable indicator of actual organ perfusion. We aim to assess postoperative blood pressure fluctuation using blood pressure variability and evaluate peripheral circulatory status via the perfusion index. In this prospective cohort study, we will examine the correlation between these two parameters and perioperative adverse events.
Interventions
- Other Blood Pressure Variability and Perfusion Index
All patients in this cohort will undergo invasive hemodynamic monitoring and noninvasive pulse oximetry, postoperative 24-hour blood pressure variability (from minute-to-minute invasive arterial pressure data) and perfusion index (from half-hourly recordings) were obtained through these monitoring modalities.
Primary outcome measures
- Incidence of the composite endpoint of adverse events within 30 days postoperatively [Time frame: Within 30 days after surgery]
Secondary outcome measures (6)
- Incidence of low cardiac output syndrome within 30 days postoperatively. [Time frame: Within 30 days after surgery]
- Incidence of acute kidney injury within 30 days postoperatively. [Time frame: Within 30 days after surgery]
- Incidence of acute respiratory distress syndrome within 30 days postoperatively [Time frame: Within 30 days after surgery]
- Incidence of new-onset atrial arrhythmias within 30 days postoperatively. [Time frame: Within 30 days after surgery]
- Incidence of prolonged ventilation (>24 hours) within 30 days postoperatively. [Time frame: Within 30 days after surgery]
- Length of intensive care unit stay [Time frame: Within 30 days after surgery]
Eligibility criteria
Inclusion criteria
- Age at surgery ≥ 18 years
- Patients admitted to the ICU for the first time after undergoing their first cardiac surgical procedure during the current hospitalization ③ Expected to receive continuous invasive blood pressure monitoring and noninvasive pulse oximetry monitoring for at least 12 hours postoperatively in the ICU ④ Written or verbal informed consent obtained from the patient or their family members
Exclusion criteria
- Patients with severe peripheral vascular disease in the arm used for noninvasive pulse oximetry monitoring
- Patients not undergoing invasive hemodynamic monitoring ③ Patients requiring preoperative or intraoperative support with IABP or ECMO
- Patients expected to have incomplete postoperative monitoring data or a monitoring duration of less than 12 hours
- Postoperative patients who are not admitted to the ICU for the first time during the current hospitalization ⑥ Patients admitted to the ICU prior to undergoing cardiac surgery ⑦ Patients with critically insufficient baseline preoperative data
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07316634 · KS2025145