The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: high sensitivity cardiac troponin.
- Who it may be relevant to
- Registry conditions: Rheumatoid Arthritis (RA, Atherosclerotic Cardiovascular Disease (ASCVD). Basic parameters: 35 years — 79 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better job of identifying individuals at risk before they develop symptoms of heart disease and start preventative treatment earlier.
Detailed description
The objective of this study is to test the utility of high sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) in risk stratifying patients with rheumatoid arthritis (RA) who may benefit from lipid lowering therapy. The population of interest are individuals who would not otherwise be recommended for therapy based on general population risk calculators for heart disease risk.
Interventions
- Diagnostic test high sensitivity cardiac troponin
Blood measurement of high sensitivity cardiac troponin
Primary outcome measures
- coronary artery calcium score [Time frame: Cross-sectional, at baseline]
Eligibility criteria
Inclusion criteria
- RA diagnosed by a rheumatologist
- Age 40- 79
- ≥1 ASCVD risk factor including prediabetes, hypertension, BMI >30, current or history of cigarette smoking
Exclusion criteria
- Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor
- Patients with diabetes mellitus
- Pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 3 centers
- Massachusetts General Hospital: Rheumatology — Boston
- Brigham and Womens Hospital — Boston
- Brigham and Women's Faulkner Hospital — Boston
Identifiers
NCT: NCT07315997 · 2024P001981