Elderly Patients Undergoing Surgery During Perioperative Period
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Postoperative Complications, Elderly, Postoperative Delirium (POD), Risk Prediction Model. Basic parameters: from 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Elderly Patients Undergoing Surgery During Perioperative Period: a Prospective Cohort Study
Overview
The elderly patients have poorer overall conditions and have lower tolerance to trauma, anesthesia, and surgery. Therefore, the incidence of postoperative complications is relatively higher. In non-cardiac surgeries, approximately 20% of elderly patients experience postoperative complications, and the incidence of postoperative delirium (POD) is 23.8%. This may lead to prolonged hospital stays, increased hospital costs, and affect prognosis and even mortality. The investigators plan to conduct a prospective cohort study by systematically collecting biological samples and clinical information of elderly patients during the perioperative period to explore the possible risk factors and pathogenesis of postoperative delirium and postoperative complications in elderly surgical patients, and to construct a risk prediction model for postoperative complications.
Primary outcome measures
- Incidence of postoperative delirium (POD) within 7 days after surgery [Time frame: Preoperative, during the first 7 postoperative days]
Secondary outcome measures (12)
- The types of postoperative delirium [Time frame: Preoperative, during the first 7 postoperative days]
- The severity of postoperative delirium [Time frame: Preoperative, during the first 7 postoperative days]
- The duration of postoperative delirium [Time frame: Preoperative, during the first 7 postoperative days]
- Postoperative neurocognitive dysfunction [Time frame: preoperative baseline, within 7 days postoperatively, and at 1, 6, and 12 months postoperatively.]
- Acute pain [Time frame: Preoperative and 3 days postoperative.]
- Hospital Anxiety and Depression Scale (HADS) score [Time frame: preoperative, 5 days, 1 month, 6 months, and 1 year postoperative.]
- Activity of Daily Living [Time frame: preoperative, 5 days, 1 month, 6 months, and 1 year postoperative.]
- Sleep quality [Time frame: preoperative, 5 days, 1 month, 6 months, and 1 year postoperative.]
- The FRAIL Scale [Time frame: preoperative, 5 days, 1 month, 6 months, and 1 year postoperative.]
- Quality of Life Score [Time frame: preoperative, 1 month, 6 months, and 1 year postoperative.]
- Mortality [Time frame: During hospitalization, 1 month, 6 months, and 1 year postoperative.]
- Length of hospitalization [Time frame: till the day of discharge from hospital, an average of 7 days]
Eligibility criteria
Inclusion criteria
1\) Surgical patients aged 65 or above or non-surgical subjects aged 65 or above. 2) Agree to participate in this study and sign the informed consent form.
Exclusion criteria
1）Refused to participate in the study.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical Universit — Wenzhou
Identifiers
NCT: NCT07314762 · SAHoWMU-CR2025-03-231