PCR for Aspergillus Fumigatus in Blood and Bronchoalveolar Lavage Fluid for Monitoring Cases of Invasive Aspergillosis: What is Its Prognostic Value
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Invasive Pulmonary Aspergillosis. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Aspergillus fumigatus PCR is currently used in conjunction with serum galactomannan to support the diagnosis of invasive aspergillosis or for monitoring at-risk patients not receiving antifungal prophylaxis. A positive result and a high titer are thought to be associated with the advanced stage of the disease and the fungal load. However, there is limited data on this subject, and no study has primarily focused on the variation of PCR levels during treatment and its potential correlation with treatment efficacy.
Primary outcome measures
- Death rate at day 30 in patients with a positive follow-up PCR (blood or bronchoalveolar lavage) [Time frame: Day 30 post-antifungal treatment]
Eligibility criteria
Inclusion criteria
- Patients aged 18 years or older
- Positive Aspergillus fumigatus PCR on serum or bronchoalveolar lavage fluid at diagnosis, performed at the Strasbourg University Hospital between January 1, 2017, and December 31, 2024.
Exclusion criteria
- No subsequent Aspergillus fumigatus PCR (>24h)
- No diagnosis of probable or proven invasive aspergillosis (EORTC/MSGERC 2020 criteria)
- Effective antifungal treatment against Aspergillus initiated before the first PCR
- Death <72h after starting antifungal treatment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France — Strasbourg
Identifiers
NCT: NCT07313527 · 9615