DPTX3186 in Wnt Pathway Activated Solid Tumors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: DPTX3186.
- Who it may be relevant to
- Registry conditions: Solid Tumors. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
An Open Label, Multicenter Study of DPTX3186 to Evaluate Safety, Tolerability, and Pharmacokinetics in Subjects With Known Wnt Pathway Activated Solid Tumors Where No Other Treatments Exist
Overview
This is a first-in human clinical study of DPTX3186 in subjects with Wnt-pathway activated solid tumors where no other treatments exist. The study will evaluate safety, pharmacokinetics, and initial activity of DPTX3186, as well as explore pharmacodynamic parameters to identify potential biomarkers of efficacy
Interventions
- Drug DPTX3186
Once daily (single dose of study drug in the morning in fasted conditions) for 4 consecutive days (4 days on) and 3 days off in a cycle of 28 days
Primary outcome measures
- Incidence of treatment emergent adverse events and serious adverse events. [Time frame: Up to 36 Months]
Eligibility criteria
Inclusion criteria
- Histologically or cytologically confirmed solid tumor and tumor types known to be Wnt-pathway activated (such as colorectal cancer, gastric cancer, lung cancer, and triple negative breast cancer) and no other approved treatment options available.
- At least one measurable target lesion as defined by RECIST v1.1 on CT, PET/CT, or MRI.
- ECOG performance status of 0 or 1.
- Physiological conditions that may prevent absorption of an oral medication including but not limited to colostomy and ileostomy.
- Age ≥18 years (or ≥ age of majority per local regulation)
- Life expectancy ≥3 months
- Willing and able to comply with protocol requirements
Exclusion criteria
- Symptomatic or uncontrolled brain metastasis requiring concurrent treatment,
- Another known malignancy that is progressing or requires active treatment within the last 2 years (except basal cell carcinoma, in situ cervical cancer, etc.).
- Inadequate organ function
- Known hypersensitivity to study drug or excipients
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Sequential
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 2 centers
- NEXT San Antonio — San Antonio
- NEXT Virginia — Fairfax
Identifiers
NCT: NCT07312903 · DPTX3186-101