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Recruiting NCT07308795

The Ultrasonographic Evaluation of Abdominal Accessory Respiratory Muscle Thickness in Patients With Parkinson's Disease: Correlation With Disease Severity and Expiratory Respiratory Muscle Strength

— Observational Parkinson Disease (PD) Maximum Inspiratory Pressure Maximum Expiratory Pressure Abdominal Accessory Respiratory Muscle Thickness

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Parkinson Disease (PD), Maximum Inspiratory Pressure, Maximum Expiratory Pressure, Abdominal Accessory Respiratory Muscle Thickness. Basic parameters: 18 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Overview

Parkinson's disease is a neurodegenerative disorder characterized by both motor and non-motor symptoms. The involvement of respiratory muscles can lead to impairments in respiratory function in these patients. In this study is to evaluate the thickness of abdominal accessory respiratory muscles using ultrasonography in patients with Parkinson's disease. Additionally, the relationship between disease severity and expiratory respiratory muscle strength will be examined. The study will include Parkinson's patients at different stages of the disease, with respiratory muscle thickness measured via ultrasonography. The collected data will then be compared with disease severity and expiratory muscle strength.

Detailed description

Parkinson's disease is a neurodegenerative disorder characterized by both motor and non-motor symptoms. The involvement of respiratory muscles can lead to impairments in respiratory function in these patients.

This observational, cross sectional study will include Parkinson's patients at different stages of the disease, with respiratory muscle thickness measured via ultrasonography. The collected data will then be compared with disease severity and expiratory muscle strength. In this study is to evaluate the thickness of abdominal accessory respiratory muscles (rectus abdominis, transversus abdominis, and oblique muscles) using ultrasonography in patients with Parkinson's disease. Additionally, the relationship between disease severity and expiratory respiratory muscle strength will be examined. Respiratory muscle strength will be assessed using maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) measurements. Disease severity will be evaluated using standardized clinical scales.

These findings will underscore the importance of evaluating respiratory muscles in Parkinson's disease and may contribute to the development of rehabilitation programs targeting respiratory muscles in the later stages of the disease.

Primary outcome measures

  • Maximal Expiratory Pressure (MEP) Measurement [Time frame: to be measured only once at the start day 1]
  • Maximal Inspiratory Pressure (MIP) Measurement [Time frame: to be measured only once at the start day 1]
  • Ultrasonographic Assessment of Abdominal Accessory Respiratory Muscles [Time frame: to be measured only once at the start day 1]

Eligibility criteria

Inclusion criteria

  • Age > 18 years
  • Parkinson's disease diagnosis with Modified Hoehn and Yahr stages 1-2-3
  • Mini-Mental State Examination (MMSE) score > 23
  • Body Mass Index (BMI) < 30

Exclusion criteria

  • Active smokers
  • Individuals with a diagnosis of active chest disease
  • Those with hemodynamic instability
  • Individuals with unstable vital signs
  • Parkinson's patients who cannot be controlled with medical treatment
  • Parkinson Plus syndromes

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Case-control

Study locations

Turkey (Türkiye) · 1 center
  • İstanbul Fizik Tedavi Ve Rehabilitasyon Eğitim Ve Araştirma Hastanesi — Istanbul

Identifiers

NCT: NCT07308795 · 2025-28

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗