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Recruiting NCT07305922

Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension

— Observational Subarachnoid Aneurysm Hemorrhage Cerebral Vasospasm After Subarachnoid Hemorrhage

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Induced hypertension with norepinephrine, Endoluminal Spasmolysis.
Who it may be relevant to
Registry conditions: Subarachnoid Aneurysm Hemorrhage, Cerebral Vasospasm After Subarachnoid Hemorrhage. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Sweden
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

An observational study of patients with emerging or established severe cerebral vasospasm after subarachnoid haemorrhage, employing multimodal neuromonitoring.

Interventions

  • Drug Induced hypertension with norepinephrine
    Induced hypertension with norepinephrine and/or dobutamine to attain clinically established goals of cerebral perfusion pressure in a stepwise fashion, according to clinical routine.
  • Drug Endoluminal Spasmolysis
    Endoluminal spasmolysis of cerebral arteries using i.a. Nimodipine, according to clinical protocol and neurointerventionist discretion.

Primary outcome measures

  • Mean Flow Velocity (MFV) [Time frame: Up to 12 hours post intervention]
Secondary outcome measures (1)
  • Duration of MFV change after Endoluminal Spasmolysis [Time frame: Up to 12 hours]

Eligibility criteria

Inclusion criteria

  • Adults 18 years or older
  • Critical care after subarachnoid haemorrhage
  • Aneurysm secured by surgical clipping or endovascular procedure
  • Suspected, emerging or established severe cerebral vasospasm

Exclusion criteria

  • Anticipated survival less than five days, as determined by treating clinician
  • Transcranial Doppler signal too weak
  • Pregnancy

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Case-only

Study locations

Sweden · 1 center
  • Karolinska University Hospital — Stockholm

Identifiers

NCT: NCT07305922 · 2025-4055

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗