Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Chronic Traumatic Encephalopathy. Basic parameters: 32 years — 60 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football. Soccer, due to repeated headers, could also be associated, albeit to a lesser degree, with the development of this type of pathology. Indeed, it has been shown that playing soccer can be accompanied by cognitive impairments, and neurodegenerative brain abnormalities have been described in neuropathology studies of former professional soccer players. Subradiological brain abnormalities have been found in multimodal MRI in various sports. Similarly, a decrease in cognitive performance has been described. The discovery of this type of anomaly in a population of professional footballers nearing the end of their careers could lead to: * The implementation of appropriate monitoring for professional footballers through early detection of lesions via MRI and cognitive disorders * The implementation of preventative measures for professional footballers, but also for amateur footballers from a very young age.
Primary outcome measures
- Changes found in MRI diffusion tensor imaging of professional football players [Time frame: day 1 post-consultation]
Eligibility criteria
Inclusion criteria
- Male subject
- Aged 32 to 60 years inclusive
- Professional footballer nearing the end of their career or recently retired, or subject who has never regularly participated in sports that expose them to head trauma (particularly rugby, basketball, handball, American football, hockey, combat sports, etc.)
Exclusion criteria
\- Subject who expressed their opposition to participating in the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- Service d'Imagerie 2 - Réanimation - CHU de Strasbourg - France — Strasbourg
Identifiers
NCT: NCT07302503 · 9451