Longitudinal Follow-up and Health-Related Outcomes in Liver Transplant Recipients and Living Donors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: liver transplantation, Living Donor Hepatectomy.
- Who it may be relevant to
- Registry conditions: Living Donor Liver Transplantation Recipients, Deceased Donor Liver Transplantation Recipients, Living Liver Donor. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors. By collecting comprehensive clinical data and conducting systematic long-term follow-up, the researchers intend to establish a specialized, standardized, and individualized follow-up management system. The ultimate goal is to optimize intervention strategies and improve patient prognosis and quality of life for both recipients and donors.
Interventions
- Procedure liver transplantation
Patients undergo standard liver transplantation according to clinical protocols. Postoperative management and follow-up are conducted per routine standard of care. Clinical data, including survival, adverse events, and quality of life (assessed by questionnaires/scales), are collected observationally at regular follow-up intervals. - Procedure Living Donor Hepatectomy
Living donors undergo standard hepatectomy procedures. Postoperative recovery and long-term health outcomes are monitored through routine follow-up visits and assessments.
Primary outcome measures
- Long-term Incidence of Postoperative Adverse Events [Time frame: From date of surgery up to 20 years]
Secondary outcome measures (3)
- Overall Survival [Time frame: Up to 20 years]
- Graft Survival Rate [Time frame: Up to 20 years]
- Patient-Reported Outcome questionnaire [Time frame: Baseline and annually up to 20 years]
Eligibility criteria
Inclusion criteria
- Patients undergoing liver transplantation or living donor hepatectomy at the study center (living donor should be approved by the hospital ethics committee for living organ donation);
- Age 18 years or older;
- Willing to participate in the long-term follow-up management program;
- Signed informed consent form;
Exclusion criteria
- Patients undergoing combined organ transplantation
- Patients with severe mental illness or cognitive impairment who are unable to cooperate with follow-up assessments.
- Donors whose surgery is aborted intraoperatively for any reason.
- Unable or unwilling to comply with the long-term follow-up schedule.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- The Second Affiliated Hospital Zhejiang University School of Medicine — Hangzhou
Identifiers
NCT: NCT07301853 · 2025-0793