Exercise Training and Vitamin D Metabolism
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Exercise training, Control.
- Who it may be relevant to
- Registry conditions: Obesity & Overweight, Vitamin D. Basic parameters: 35 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Greece
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Impact of Hybrid-type High-intensity Interval Training on Vitamin D Metabolism in Adults With Overweight/Obesity
Overview
The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal body mass index (BMI). The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D \[25(OH)D\] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.
Detailed description
Thirty adults with overweight/obesity (both males and females) who will meet the inclusion criteria will be randomly assigned to either an Exercise group (n=15) or a Control group (n=15). The Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet. The Control group will receive a balanced diet but will not participate in exercise training. Both groups will provide a resting blood sample and undergo assessment of their body composition (via bioelectrical impedance analysis), daily dietary intake (via dietary recalls) and physical activity level (via accelerometry) at baseline (prior to intervention), 6 weeks and 12 weeks.
Interventions
- Other Exercise training
Receive a balanced diet and participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period - Other Control
Receive a balanced diet but abstain from any type of exercise training
Primary outcome measures
- Change in 25-hydroxyvitamin D concentration [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in plasma Vitamin D binding protein concentration [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in calcium concentration [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in albumin concentration [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in aspartate aminotransferase (SGOT) concentration [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in alanine aminotransferase (SGPT) concentration [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in gamma-glutamyl transferase (γ-GT) concentration [Time frame: At baseline, 6 weeks and 12 weeks]
Secondary outcome measures (5)
- Change in reduced glutathione concentration [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in oxidized glutathione concentration [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in dietary intake [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in physical activity level [Time frame: At baseline, 6 weeks and 12 weeks]
- Change in body composition [Time frame: At baseline, 6 weeks and 12 weeks]
Eligibility criteria
Inclusion criteria
- BMI = 25-35 kg/m2
- Absence of musculoskeletal injuries
- Absence of chronic health-related complications
- Non-smokers
Exclusion criteria
- Consumption of Vitamin D supplements
- Consumption of anti-inflammatory drugs, statins and/or steroids
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Other
Study locations
Greece · 1 center
- Department of Physical Education and Sport Science, University of Thessaly — Trikala
Identifiers
NCT: NCT07300332 · UTH_2612_8.10.2025