Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Cold temperature, Room Temperature.
- Who it may be relevant to
- Registry conditions: Exercise. Basic parameters: 18 years — 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation: A Pilot Study
Overview
The purpose of this research study is to determine if the cold-induced change in fat burning during exercise is different between females and males.
Detailed description
It is well characterized that females rely more on fat oxidation compared to men during standardized exercise. Exposure to cold during exercise increases fat oxidation in humans. It has been shown that the biological sex differences in substrate oxidation observed during exercise persist in the cold. However, it is unclear if the degree of the effect of cold on substrate oxidation during exercise is different between females and males.
The purpose of this study is to determine if the change in maximal fat oxidation that occurs in cold compared to room temperature environments is different between females and males.
The hypotheses are 1) females will have greater maximal fat oxidation than males in both conditions, and 2) the change in maximal fat oxidation between the control and cold conditions will be the same in females and males.
Interventions
- Other Cold temperature
Room temperature will be decreased to 5 ºC - Other Room Temperature
Exercise condition for control arm
Primary outcome measures
- Maximal Fat Oxidation [Time frame: During exercise while in the lab]
Eligibility criteria
Inclusion criteria
- Age 18-40 years (inclusive)
- Weight stable (no change in body mass greater than 5 lbs. within the previous 6 months.
- Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits
- Competency in English as informally assessed by comprehension of the Informed Consent. This study involves maximal exercise testing; for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.
- Regular exercise (i.e., at least 150 minutes of moderate-vigorous exercise per week)
Exclusion criteria
- Use of hormonal contraceptives
- History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
- Pregnancy or breast feeding
- Habitual use of tobacco/nicotine products or recreational drugs (2 or more uses within the previous month)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Open label
- Primary purpose
- Other
Study locations
United States · 1 center
- Colorado State University — Fort Collins
Identifiers
NCT: NCT07297823 · 7231