Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Sevoflurane, Desflurane.
- Who it may be relevant to
- Registry conditions: Perioperative Respiratory Mechanics. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Laparoscopic Cholecystectomy Patients: Effect of Sevoflurane vs. Desflurane on Mechanical Power - A Prospective, Randomized, Controlled Trial
Overview
This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).
Interventions
- Drug Sevoflurane
General anesthesia will be maintained with sevoflurane at 2% concentration in patients assigned to the Sevoflurane Group (Group S). Standardized ventilator settings will be applied for all participants, and mechanical power will be measured at three intraoperative time points while sevoflurane is used as the sole maintenance inhalational agent. - Drug Desflurane
Maintenance of general anesthesia with desflurane 6% during laparoscopic cholecystectomy. Mechanical power is measured at three intraoperative time points using standardized ventilator settings.
Primary outcome measures
- Mechanical Power (MP) during General Anesthesia [Time frame: Measured at three intraoperative time points: Post-intubation baseline (MP1) 15 minutes after pneumoperitoneum (MP2) End of surgery before emergence (MP3)]
Eligibility criteria
Inclusion criteria
- Adults aged 18-65 years
ASA Physical Status I-II
Scheduled for elective laparoscopic cholecystectomy
Able to provide written informed consent
Exclusion criteria
Known hypersensitivity or contraindication to study medications (sevoflurane or desflurane)
Severe chronic obstructive pulmonary disease (COPD)
Uncontrolled bronchial asthma
Decompensated heart failure (NYHA Class III-IV)
History of prior lung surgery
Morbid obesity (BMI > 35 kg/m²)
Pregnancy
Refusal to participate or inability to provide informed consent
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Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Prevention
Study locations
Turkey (Türkiye) · 1 center
- Konya City Hospital — Konya
Publications
- Jo YY, Chang YJ, Lee D, Kim YB, Jung J, Kwak HJ. Comparisons of Mechanical Power and Respiratory Mechanics in Pressure-Controlled Ventilation and Volume-Controlled Ventilation during Laparoscopic Cholecystectomy in Elderly Patients. J Pers Med. 2023 Jan 23;13(2):201. doi: 10.3390/jpm13020201. PMID 36836435
Identifiers
NCT: NCT07295158 · LC-MP-2025-01"