Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Allium Sativum as an intracanal medicament.
- Who it may be relevant to
- Registry conditions: Apical Periodontitis, Periapical Radiolucency. Basic parameters: 15 years — 45 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth: A Randomized Controlled Trial.
Overview
Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and antimicrobial characteristics. Because conventional medicaments can be expensive or have potential side effects, researchers are actively exploring natural options like garlic. Some lab studies have already shown that garlic gel can kill the microbes inside the teeth. However, no real-life clinical or X-ray studies have been done on using garlic in permanent teeth. This study may help scientists find a much safer and effective new material for dental treatments in the future.
Detailed description
Clinical trials are needed to evaluate the effectiveness of Allium sativum as an intracanal medicament due to its various useful properties, such as anti-inflammatory, wound healing action, and antimicrobial properties. To overcome the problems with synthetic medicament, researchers are looking for natural alternatives due to their low cost, easy availability, and safety. The objective of the study is to evaluate and compare the clinical and radiographic treatment outcomes of using garlic gel and calcium hydroxide paste as an intracanal medicament in nonsurgical root canal treatment of permanent teeth in terms of:
* Pain. * Tenderness to palpation. * Tenderness to percussion. * Size of Periapical radiolucency.
Interventions
- Drug Allium Sativum as an intracanal medicament
Patients will receive informed consent, clinical exam, and preoperative radiographs. After anesthesia and rubber dam isolation, access, cleaning, and shaping of canals will be performed using standard endodontic techniques. A sterile paper point will be placed in the canal for pH evaluation, followed by placement of garlic gel with lentulo spiral and temporary restoration of MD Temp and GC Gold Label 2 GIC. Patients will return after 14 days; if symptoms persist, the medicament will be replaced,
Primary outcome measures
- CLINICAL AND RADIOGRAPHIC OUTCOMES [Time frame: Time frame for clinical outcomes: Baseline to 2 weeks Time frame for radiographic outcomes: Baseline to 6 months]
Eligibility criteria
Inclusion criteria
- Patients with the physical status of ASA I and ASA II according to ASA classification.
- Patients aged from 15-45 years.
- Mature permanent single-rooted teeth with closed apices.
- Patients with clinical signs of symptomatic apical periodontitis (pain, tenderness to palpation, and percussion).
- Patients having radiographic evidence of periapical radiolucency of endodontic origin.
- Patients who have not taken antibiotics for the past 14 days.
- Cooperative patients who show good compliance.
Exclusion criteria
- Patients with physical status of ASA III, IV, and V according to ASA classification.
- Teeth with a calcified pulp chamber in periapical radiography.
- Patients who have undergone previous endodontic treatment failure and those with the presence of sinus tract on clinical examination.
- Teeth having advanced periodontal disease, with the basic periodontal examination (BPE) of 3 and 4.
- Presence of internal and external resorption of the root as viewed on the periapical radiograph.
- Presence of vertical root fracture and perforation as viewed on the periapical radiograph
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Faghihi T, Haghgoo R, Taghizade F, Zareiyan M, Mehran M, Ansari G. The clinical and radiographic evaluation of Allium sativum oil (garlic oil) in comparison with mineral trioxide aggregate in primary molar pulpotomy. Dent Res J (Isfahan). 2021 Nov 22;18:100. doi: 10.4103/1735-3327.330881. eCollection 2021. PMID 35003565
Identifiers
NCT: NCT07289971 · 00/220/22