Assessment of Kidney Function in Patients With Epilepsy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Standard Clinical Observation.
- Who it may be relevant to
- Registry conditions: Epilepsy. Basic parameters: 1 months — 15 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This observational cross-sectional study aims to assess kidney function in pediatric patients with epilepsy attending Sohag University Hospital. The study evaluates renal biochemical markers, urinalysis, liver functions, abdominal ultrasonography, and the possible renal effects of long-term antiepileptic drug (AED) therapy.
Detailed description
Epilepsy is one of the most common neurological disorders requiring long-term antiepileptic drug therapy. Many AEDs are metabolized hepatically but excreted renally, which may affect kidney function, especially with long-term use. Several AEDs-including topiramate, zonisamide, acetazolamide, carbamazepine, and valproate-have been associated with nephrolithiasis, tubular dysfunction, nephrotoxicity, and acute kidney injury.
The study evaluates renal function among children with idiopathic epilepsy using clinical assessment, laboratory markers (CBC, serum creatinine, electrolytes, ABG, urinalysis, liver functions), EEG findings, and abdominal ultrasound. The purpose is to estimate the prevalence of renal affection and its possible relation to AED use.
This observational cross-sectional study evaluates renal function in pediatric patients with epilepsy by measuring serum creatinine levels at the time of enrollment. The study will enroll children of various ages and both sexes, representing multiple epilepsy types and receiving different antiepileptic drug regimens.
Comprehensive baseline data, including demographic characteristics, medical history, seizure type and frequency, and current medication usage, will be collected. Venous blood samples will be obtained for serum creatinine measurement using validated clinical laboratory methods, ensuring standardized assessment of renal function.
The study's primary objective is to determine baseline renal function in this population and to investigate potential associations between antiepileptic drug therapy and renal outcomes. Secondary analyses will explore correlations between serum creatinine levels and patient-specific factors such as age, sex, epilepsy type, duration of therapy, and comorbidities.
All data will be handled in accordance with institutional and regulatory guidelines for clinical research. The results are intended to inform clinical monitoring practices, optimize antiepileptic drug management, and support future research on kidney function in children with epilepsy.
Interventions
- Behavioral Standard Clinical Observation
Observational study of pediatric patients admitted to Sohag University Hospital. No experimental treatment or device is administered. Data collection only.
Primary outcome measures
- Serum creatinine level in pediatric epilepsy patients [Time frame: At enrollment (single cross-sectional assessment)]
Secondary outcome measures (5)
- Prevalence of nephrolithiasis / nephrocalcinosis [Time frame: At enrollment (single cross-sectional assessment)]
- Electrolyte disturbances [Time frame: At enrollment (single cross-sectional assessment)]
- Abnormal urinalysis findings [Time frame: At enrollment (single cross-sectional assessment)]
- Association between AED regimen and renal parameters [Time frame: At enrollment (single cross-sectional assessment)]
- Abdominal Ultrasound Findings [Time frame: At enrollment (single cross-sectional assessment)]
Eligibility criteria
Inclusion criteria
- Age: children between 1month and 15years old.
- Both sexes.
- children who suffering from idiopathic epilepsy
Exclusion criteria
- Age: children below 1month old\& children above 15 years old.
- Children suffer from convulsions due to CNS infection
- Children with non idiobathic epilepsy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Egypt · 2 centers
- Sohag University — Sohag
- Sohage Faculty of Medicine — Sohag
Identifiers
NCT: NCT07288788 · Soh-Med--25-9-2MS