Clinical Characteristics and Molecular Mechanism of Patients With Obstructive Sleep Apnea
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Obstructive Sleep Apnea. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
To clarify the clinical features of patients with obstructive sleep apnea; To construct a multi-omics database of patients with obstructive sleep apnea, and compare the effects of different degrees of sleep apnea on prognosis, immunity, and metabolism. The medium and long-term prognosis, complications, comorbidities, risk factors, and immune and metabolic dynamics of patients with sleep apnea after treatment were studied. To elucidate the biomarkers and therapeutic targets associated with obstructive sleep apnea.
Primary outcome measures
- Multiple-omics features [Time frame: Within 24 hours of admission，and samples of patients receiving treatment were also collected six months and one year after treatment]
Eligibility criteria
Inclusion criteria
- Patients with suspected obstructive sleep apnea (OSA) admitted to the sleep center of the respiratory Department of Beijing Chaoyang Hospital, Capital Medical University.
- Volunteer to participate in the study and sign an informed consent, and can complete at least 1 year of follow-up.
Exclusion criteria
- Patients with obstructive sleep apnea who have been treated with impermanent positive pressure ventilation;
- Pregnant or lactating women;
- Patients with severe respiratory failure requiring mechanical ventilation;
- Patients with severe heart, lung, liver, kidney, and central nervous system damage;
- Refuse to participate in follow-up visits and/or take biological samples.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Beijing Chaoyang hospital affiliated to Capital Medical University — Beijing
Identifiers
NCT: NCT07277608 · 2023-ke-450