Adrenaline V/s Dopamine in Fuid Refractory Septic Shock
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Adrenaline, Dopamine.
- Who it may be relevant to
- Registry conditions: Fluid Refractory Septic Shock, Septic Shock. Basic parameters: 1 months — 12 months · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Pakistan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparison of the Efficacy of Renaline and Dopamine in the Treatment of Fluid Refractory Septic Shock in Children
Overview
This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children. The efficacy will be checked based on heart rate , GCS, capillary refill time , palpable pripheral pulse , urine output and systolic blood pressure.
Detailed description
This is a randomized control trial in which children / patients diagnosed with Fluid refractory Septic shock will be provided with one of the two drugs ina randomzied way and their efficacy will be assesed on the basis of correction of various parameters at various points of time.
Interventions
- Drug Adrenaline
The adrenaline will be given as a vasoconstrictor in the dose of 0.1-0.3ug/kg/min to the patients in group A when diagnosed with fluid refractory septic shock - Drug Dopamine
The drug dopamine will be adminitered in dose of 10-20ug/kg/min to the patients of group B when diagnosed with fluid refractory septic shock.
Primary outcome measures
- Blood Pressure [Time frame: 6 hours]
- Pulse [Time frame: 6 hours]
- Capillary Refill Time [Time frame: 6 Hours]
- Urine output [Time frame: 6 hours]
- GCS [Time frame: 6 hours]
Secondary outcome measures (1)
- SOFA ( Sequential Organ Failure Assesment) [Time frame: 6 Hours]
Eligibility criteria
Inclusion criteria
Patients of both Genders having age range between 1month and 12 years with diagnosis of fluid refractory septic shock as per operational definition.
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Exclusion criteria
- Patients with
- cardiopumonary Bypass during last 5 days
- Chronic Systemic disease like Chronic kidney Disease , cerebral palsy, congenital heart disease
- neuromuscular discorder
- Metabolic disorders
- Those who already had treatment at periphery for hypovolemia without any record of medication or sequential organ failure at presentation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Pakistan · 1 center
- The Children Hospital and The Institute of Child Health Faisalabad — Faisalābad
Identifiers
NCT: NCT07273526 · #AVDSSC24#