Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Subcostal and lateral transversus abdominis plane block, Thoracic epidural anesthesia.
- Who it may be relevant to
- Registry conditions: Subcostal, Lateral, Transversus Abdominis Plane Block, Postoperative Analgesia. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Safety and Efficacy of Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery
Overview
This study aims to evaluate the safety and efficacy of combined subcostal and lateral transversus abdominis plane (TAP) for postoperative analgesia versus thoracic epidural anesthesia (TEA) in patients undergoing major abdominal cancer surgery.
Detailed description
Postoperative pain is treated using a variety of techniques. It is possible to deliver opioids intravenously, neuraxially, or both.
Thoracic epidural anesthesia (TEA) has long been considered the benchmark for analgesia in major abdominal operations due to its consistent efficacy in pain control and additional benefits such as reduced ileus and improved pulmonary function.
Transversus abdominis plane (TAP) blocks can be a critical component of postoperative pain management, and they play a crucial role in Enhanced Recovery After Surgery (ERAS) protocols, as they significantly affect recovery and patient well-being.
Interventions
- Other Subcostal and lateral transversus abdominis plane block
Patients will receive an ultrasound-guided combined subcostal and lateral transversus abdominis plane block. - Other Thoracic epidural anesthesia
Patients will receive an ultrasound-guided thoracic epidural anesthesia.
Primary outcome measures
- Total morphine consumption [Time frame: 24 hours postoperatively]
Secondary outcome measures (5)
- Time to the 1st rescue analgesia [Time frame: 24 hours postoperatively]
- Mean arterial pressure [Time frame: Till the end of surgery (Up to 2 hours)]
- Heart rate [Time frame: Till the end of surgery (Up to 2 hours)]
- Degree of pain [Time frame: 24 hours postoperatively]
- Incidence of adverse events [Time frame: 24 hours postoperatively]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years.
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status I-III.
- Scheduled for major abdominal surgeries including: (e.g., gastrectomy, colectomy, hepatectomy, cystectomy, total abdominal hysterectomy, Nephrectomy, pancreatectomy).
Exclusion criteria
- Intraoperative hemodynamic instability.
- History or evidence of coagulopathy.
- Infection or abdominal wall masses at injection site.
- Morbid obesity.
- Other Medical conditions including mental illness or substance abuse.
- Known allergy to local anesthetics.
- Chronic opioid use or chronic pain conditions.
- Pregnancy.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Assiut University — Asyut
Identifiers
NCT: NCT07273136 · 620