Research on Anesthesia Depth Control Strategy Based on Continuous and Non-invasive Monitoring of Exhaled Breath
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Anesthesia. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study aims to propose a strategy for controlling the depth of anesthesia based on continuous and non-invasive monitoring of exhaled breath: BIS value during intravenous-inhalation combined anesthesia is predicted according to the real-time exhaled concentrations of sevoflurane and propofol, so as to achieve the depth of anesthesia management for patients who cannot use standard BIS. Furthermore, the relationship between anesthetic concentration and depth of anesthesia was analyzed in different subgroups.
Primary outcome measures
- Correlation and consistency analysis between exhaled breath concentrations of two anesthetics and BIS values [Time frame: 1 day]
- Establish a 3D drug dose-effect model of the exhaled concentration and BIS value of anesthetics [Time frame: 1day]
Secondary outcome measures (2)
- Correlation and consistency analysis of exhaled breath concentration and blood concentration of anesthetics [Time frame: 1day]
- The incidence of adverse reactions [Time frame: 72 hours]
Eligibility criteria
Inclusion criteria
- Age ≥18 years old
- ASA I-III
- Expected duration of surgery > 1 hour
- Radial artery catheterization was performed
- Patients requiring BIS monitoring.
Exclusion criteria
- Patients with contraindications to general anesthesia
- mental disorder, unable to answer
- long-term use of antiepileptic drugs and psychotropic drugs
- pregnant patients
- patients refused to participate
- the investigator thought that the study was not suitable for inclusion
- patients who did not wake up in PACU
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Second Affiliated Hospital, School of Medicine, Zhejiang University — Hangzhou
Identifiers
NCT: NCT07272044 · 2023-1166