Improving Control of Intermittent Exotropia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: dichoptic videos, standard videos.
- Who it may be relevant to
- Registry conditions: Intermittent Exotropia. Basic parameters: 4 years — 10 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
To determine whether use of dichoptic movies for 8 weeks may be helpful in improving control alignment in children with intermittent exotropia (IXT), thus allowing IXT to be managed non-surgically
Detailed description
Intermittent exotropia (IXT) is the most common form of strabismus, characterized by an outward deviation of the eyes that is primarily manifest during distance fixation and can intermittently be controlled by fusional mechanisms. Less than 30% of children have good long-term outcomes following treatment for spontaneously manifest IXT with current non-surgical treatments (prism therapy, over-minus lenses, or vision therapy). The limited efficacy of current non-surgical treatments for IXT is thought to arise from underlying sensory deficits, particularly interocular suppression, which compromises binocular function. This underscores the need for sensory-directed interventions aimed at reducing suppression and thereby enhancing the potential for stable binocular outcomes.
In this study, children will be randomized to watch engaging videos streamed at home that are either dichoptic or standard (control) format. The aim is to determine whether the dichoptic format will decrease suppression and improve control of eye alignment . In previous research, use of dichoptic games and movies by children with amblyopia has shown to reduce suppression.
Interventions
- Other dichoptic videos
custom designed dichoptic videos - Other standard videos
standard videos
Primary outcome measures
- Improvement in control of intermittent exotropia [Time frame: 8 weeks]
Secondary outcome measures (7)
- Improvement in control of intermittent exotropia [Time frame: 4 weeks]
- Improvement in control of intermittent exotropia [Time frame: 12 weeks off-treatment]
- Change in distance stereoacuity [Time frame: 4 weeks]
- Change in distance stereoacuity [Time frame: 8 weeks]
- Change in distance stereoacuity [Time frame: 12 weeks off-treatment]
- Change in quality of life [Time frame: 8 weeks]
- Change in quality of life [Time frame: 12 weeks off-treatment]
Eligibility criteria
Inclusion criteria
- Diagnosis of IXT or XT at Distance \& IXT or XP at near (Basic or Pseudo Divergence Excess subtype of IXT)
- No surgery planned for 6 months
Exclusion criteria
- Prior eye muscle surgery
- Prior binocular treatment or vision therapy
- Amblyopia
- Neurological conditions, seizure disorders, vestibular abnormalities, or frequent headache
- Other eye conditions (refractive error OK)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Retina Foundation of the Southwest — Dallas
Identifiers
NCT: NCT07272005 · 03 IXT2 2026