Total Intravenous Anesthesia (TIVA) Versus Inhalational Anesthesia at The End of Laparoscopic Obstetric Surgery Regarding Postoperative Nausea and Vomiting
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: inhalational anaesthesia, total intravenous anesthesia (TIVA).
- Who it may be relevant to
- Registry conditions: Laparoscopic Obstetric Surgery. Basic parameters: 18 years — 50 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Postoperative nausea and vomiting (PONV) remain among the most common and distressing complications after general anaesthesia, with important consequences for patient comfort, satisfaction, recovery trajectories, and length of stay following surgery. The incidence of PONV is especially high after laparoscopic and gynaecological procedures due to patient- and procedure-related risk factors, making effective prevention and management a priority in perioperative care \[5,8\]. Anaesthetic technique is a recognized, modifiable determinant of PONV. Numerous clinical trials and randomized studies have demonstrated that the choice between propofol-based total intravenous anaesthesia (TIVA) and volatile inhalational maintenance can materially influence PONV incidence. Propofol-based TIVA has been repeatedly associated with lower rates of early and overall PONV compared with volatile agents in diverse surgical populations, supporting its role as an antiemetic strategy in addition to pharmacologic prophylaxis \[1,2,4,9\]. Trials specifically conducted in gynaecological and laparoscopic surgical populations report consistent reductions in nausea and vomiting with propofol maintenance compared with isoflurane or other volatile agents. These procedure-specific data are directly relevant to studies in gynecological laparoscopy, where baseline PONV risk is elevated and where anesthetic technique may yield a clinically meaningful reduction in patient morbidity \[5,8,9\]. Meta-analyses and systematic reviews pooling randomized controlled trials provide higher-level evidence that TIVA reduces the relative risk of PONV compared with volatile anaesthesia. Trial-sequential and pooled analyses estimate a clinically important risk reduction favoring TIVA, although effect sizes vary with study populations, prophylactic antiemetic regimens, and outcome time windows; these syntheses underpin the rationale for a targeted randomized comparison in the gynecological laparoscopic setting \[2,4,10\].
Interventions
- Procedure inhalational anaesthesia
patients will be offed from inhalational anesthesia - Procedure total intravenous anesthesia (TIVA)
patients will be Switched Total Intravenous Anesthesia (TIVA)
Primary outcome measures
- Incidence of post operative neasea [Time frame: 24 hours]
- incidance of postoperative vomting [Time frame: 24 hours]
Eligibility criteria
Inclusion criteria
- Female, age 18-50 years.
- Elective laparoscopic procedure under general anaesthesia with endotracheal intubation.
- Expected surgical duration ≥ 30 minutes. -.Ability to consent and complete questionnaires
Exclusion criteria
- Pregnancy or lactation.
- BMI ≥ 40 kg/m²; severe cardiopulmonary disease; hepatic/renal failure.
- History of malignant hyperthermia or contraindication to study drugs.
- Known allergy to propofol, , , sevoflurane/desflurane.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07270289 · tiva vs inhala anesth in ponv