Ultrafast Ultrasound Imaging in Pediatric Cardiology
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Cardiac Ultrafast Ultrasound.
- Who it may be relevant to
- Registry conditions: CHD - Congenital Heart Disease. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Ultrafast Ultrasound Imaging: Application in Pediatric Cardiology: Cardiac Ultrafast
Overview
About 13 in 1000 children are born with heart disease. Current tools poorly assess heart filling in children, limiting treatment. This study explores ultrafast ultrasound imaging to measure heart stiffness and perfusion in children with congenital heart disease.
Detailed description
About 13/1000 children are born with heart disease. As a result of better treatment, there is an increasing population of children surviving with congenital heart disease (CHD) as well as a growing number of children with obesity, hypertension and serious chronic diseases, such as cancer and kidney disease, who are at risk of developing heart disease. All of these diseases affect the heart muscle and one of the main mechanisms resulting in heart muscle damage is the development of scar tissue (fibrosis). Fibrosis makes the heart muscle stiffer and therefore more difficult to fill. The heart must fill properly with blood in order to function well; but it is very difficult to study the filling of the heart using current diagnostic tools. One of the main challenges in pediatric cardiology is that non-invasive diagnostic approaches used in adult patients to assess heart filling (diastolic function) have proven inadequate in children. This knowledge gap has limited therapeutic progress in this vulnerable population; and to date there is no effective therapy that improves the filling of the heart.
The aim of this study is to explore new potential of ultrasound to assess diastolic function in CHD children. Ultrafast ultrasound imaging (UFUS), consisting of ultrasound images at a very high rate, is a new ultrasound approach to assess cardiac function.
Using a Verasonics system (ultrasound open platform), we will assess the myocardial stiffness and the myocardial perfusion by UFUS.
Interventions
- Other Cardiac Ultrafast Ultrasound
Ultrafast ultrasound imaging(UFUS), ultrasound images at a very high rate, using a Verasonics system (ultrasound open platform).
Primary outcome measures
- Myocardial stiffness [Time frame: Baseline]
- Myocardial perfusion [Time frame: Baseline]
Secondary outcome measures (1)
- Echocardiographic parameters [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- Every patient of CHD department of any age or any sex:
- Patients with CHD
- General population patients in good general health as evidenced by medical history coming to our department for a check-up OR diagnosed with small Atrial Septal Defect or small Patent Foramen Ovale
- Social security affiliation
- Parental or legal guardian's non-opposition
Exclusion criteria
- Arrhythmia
- Segmental kinetic disorder.
- Pacemaker or multisite stimulation, defibrillator,
- Anechoic
- Allergy to echocardiography gel.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
France · 1 center
- Hôpital Cardiologique Haut Lévêque — Pessac
Identifiers
NCT: NCT07255144 · CHUBX 2024/52 · CER-BDX 2024-169