Neurological Manifestations in Children Diagnosed With Inflammatory Bowel Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: IBD (Inflammatory Bowel Disease). Basic parameters: 1 year — 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Neurological Manifestations in Children Diagnosed With Inflammatory Bowel Disease in Assiut University Child Hospital
Overview
screen for neurologic and psychiatric disorders in children and adolescents with IBD.
Detailed description
Neurologic symptoms have a great importance in early diagnosis and
treatment preventing major morbidity and later sequelae, especially if they
precede GI symptoms
The prevalence of neurologic manifestations of IBD varies between 0.2% and
36%. Their pathogenesis of neurologic manifestations in IBD consists of 6
mechanisms: 1.malabsorption and nutritional deficiency 2.metabolic agents
3.infections complicating immune suppression 4.side effects of medications or
iatrogenic as a surgical complication 5.thromboembolism 6.immunological
factors
UC patients are similar to or higher than CD patients in the probability of
neurologic symptoms. Neurologic manifestations and complications include:
headache, dizziness, hypotonia, ADHD, tics, sensory complaints, seizures,
neuropsychiatric disorders, peripherial neuropathy, meningitis, vestibular
dysfunction, idiopathic IC hypertension, cerebral vasculitis, demyelinating
disorders and migraine
Primary outcome measures
- Screening for Neurological manifestations among children diagnosed with inflammatory bowel disease in Assiut university children hospital [Time frame: during the period from January 2026 to January 2027.]
- screen for neurologic and psychiatric disorders in children and adolescents with IBD. [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- patients with IBD aged from from 1 to18 years old.
Exclusion criteria
- patients with IBD and aged above 18 years old or below 1 year old
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Alsakarneh S, Ahmed M, Jaber F, Abuassi M, Mourad FH, Francis FF, Barada K, Tfayli R, Al-Bawardy B, Farraye FA, Hashash JG. Inflammatory bowel disease burden in the Middle East and North Africa Region: a comprehensive analysis of incidence, prevalence, and mortality from 1990-2019. Ann Gastroenterol. 2024 Sep-Oct;37(5):527-535. doi: 10.20524/aog.2024.0909. Epub 2024 Aug 19. PMID 39238799
- Kliegman, Nathan J. Blum, Robert C. Tasker, Karen M. Wilson, Joseph W. St Geme, Abigail M. Schuh, Cara L. Mack, Matthew A. Deadorf, Nelson textbook of pediatrics edition 22, Elseveir, vol 2, 2024, pp 2309- 2325.
- Ben-Or O, Zelnik N, Shaoul R, Pacht A, Lerner A. The neurologic profile of children and adolescents with inflammatory bowel disease. J Child Neurol. 2015 Apr;30(5):551-7. doi: 10.1177/0883073814521296. Epub 2014 Apr 2. PMID 24700662
- Zhao M, Gonczi L, Lakatos PL, Burisch J. The Burden of Inflammatory Bowel Disease in Europe in 2020. J Crohns Colitis. 2021 Sep 25;15(9):1573-1587. doi: 10.1093/ecco-jcc/jjab029. PMID 33582812
- Mosli M, Alawadhi S, Hasan F, Abou Rached A, Sanai F, Danese S. Incidence, Prevalence, and Clinical Epidemiology of Inflammatory Bowel Disease in the Arab World: A Systematic Review and Meta-Analysis. Inflamm Intest Dis. 2021 Sep 7;6(3):123-131. doi: 10.1159/000518003. eCollection 2021 Sep. PMID 34722642
- ulia Gorospe, Joseph Windsor, Lindsay Hracs, Stephanie coward, Michael Buie, Joshua Quan, Lea Caplan, Trends in infammatory bowel disease incidence and prevalence across epidemiologic stages: a global systematic review with meta-analysis, the crohns and colitis foundation and AGA institute, 2024.
- Gordon H, Burisch J, Ellul P, Karmiris K, Katsanos K, Allocca M, Bamias G, Barreiro-de Acosta M, Braithwaite T, Greuter T, Harwood C, Juillerat P, Lobaton T, Muller-Ladner U, Noor N, Pellino G, Savarino E, Schramm C, Soriano A, Michael Stein J, Uzzan M, van Rheenen PF, Vavricka SR, Vecchi M, Zuily S, Kucharzik T. ECCO Guidelines on Extraintestinal Manifestations in Inflammatory Bowel Disease. J Cr PMID 37351850
- Rogler G, Singh A, Kavanaugh A, Rubin DT. Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management. Gastroenterology. 2021 Oct;161(4):1118-1132. doi: 10.1053/j.gastro.2021.07.042. Epub 2021 Aug 3. PMID 34358489
Identifiers
NCT: NCT07247994 · EIMs in Children with IBD