Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Liver Transplantation. Basic parameters: from 14 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Innovative Technology Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension
Overview
The objective of this observational study is to compare the safety profile of auxiliary liver transplantation using small-for-size grafts with that of conventional liver transplantation and to evaluate the efficacy of this technique. The primary research question it seeks to investigate is: "What are the differences in safety and efficacy between auxiliary liver transplantation utilizing small-for-size grafts and conventional liver transplantation for the treatment of portal hypertension?"
Primary outcome measures
- overall survival [Time frame: Within one year after liver transplantation]
- Complications [Time frame: Within one year after liver transplantation]
- portal hypertension resolution [Time frame: Within one year after liver transplantation]
Eligibility criteria
Inclusion criteria
- Age > 14 years.
- Presence of decompensated portal hypertension.
- Meeting the indications for liver transplantation surgery.
- International Normalized Ratio (INR) < 2.4.
- Scheduled to undergo orthotopic auxiliary partial liver transplantation or conventional liver transplantation.
Exclusion criteria
- Rare liver-related anatomical variations.
- Presence of contraindications to liver transplantation combined with malignant tumors.
- Grade III or higher portal vein thrombosis.
- Severe systemic diseases unrelated to the etiology or complications of portal hypertension.
- Special surgical procedures such as dual-graft liver transplantation.
- Special graft sources including domino liver transplantation.
- Liver re-transplantation.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07247877 · BFHHZML20250022