Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression

The proposed study is a single center study investigating the effect of ketamine modulation on the brain signature of treatment resistant depression (TRD). The patients will undergo 2 scanning visits (baseline and follow-up). They will also receive 1-2 treatments of ketamine IM injection and 3-4 psychotherapy sessions.

Patients with TRD will be asked to come to the PI's lab for 2 visits, and 6 in the Department of Psychiatry. On visit 1, after consenting and doing the drug screen, the subjects will be asked questions on their depression experience. Subjects will then fill out demographic and clinical questionnaire to assess mood, anxiety, pain, history of early trauma, and stress. Patients will be asked to rate their depression and pain level using a visual analogue scale (VAS).

During visit 1, Drs. Geha and Swogger will interview the patients to inquire about any prior drug allergies including allergies to medications that could be possibly used in this study (ketamine/ondansetron/lorazepam/clonidine). Possible side effects will be explained to the patients. They will then undergo 60 minutes of functional and structural brain scanning, which will serve as a baseline scan.

Visits 2 and 3 will be psychotherapy sessions with Dr. Swogger to prepare for the ketamine session and focus on their difficulties and goals for the medicine session. Strategies for working with ketamine will be reviewed.

Visits 4 and 6 will be the ketamine IM injection sessions. Visit 4 they will receive 0.5 mg/kg but will not exceed 60 mg regardless of weight. Visit 6 may be a higher dose, but will not exceed 60 mg. The dose will be determined by Drs. Geha and Swogger based on the patients' experience and response in visit 4. Ondansetron will be available for nausea, lorazepam for uncontrolled agitation, and clonidine for uncontrolled hypertension. Throughout the visits members of the study team will be present to ensure patient comfort and offer reassurance, redirection, etc. They will also take notes for later processing in psychotherapy visits. When the patient emerges from non-ordinary state of consciousness, they will complete the MEQ, and the study team will complete CADSS-6 and record any other pertinent information about the experience. Once it is deemed safe, the patient may leave via someone driving them home after the visit and will be instructed on safety measures for the rest of the day.

Visits 5 and 7 will be follow up psychotherapy visits the day after the ketamine treatment. They will discuss and process the experience. If the patient wishes not to receive another dosage, then visit 7 will not occur and they will proceed with visit 8 after visit 5.

Visit 8 is conducted in the PI's lab about 4 weeks after visit 5 (one dose) or 7 (two doses). This will include answering similar questionnaires from the baseline visit to assess depression, pain, anxiety, mood, trauma, and personality. The patient will discuss the accessibility and feasibility of the study with Dr. Swogger or a member of the study team. Then they will conduct a follow up functional and structural brain imagining scan, lasting for 60 minutes.

For 7 days after visit 1, 7 days after each ketamine session, and 7 days before visit 8, the patient will complete quick at home surveys to assess depression and pain.

Throughout the study the investigators will assess depression, mood, pain, and Openness to Experience using the questionnaires below:

* Hamilton Depression Rating Scale (HDRS or HAM-D): Clinical tool that assesses the severity of depression. Includes 17 questions that assess depressed mood, suicidal ideation, anxiety, and somatic symptoms. * Beck Depression Inventory (BDI): A 21-item questionnaire that measures depression. It is not used to diagnose, but to monitor presence and severity of symptoms and for monitoring treatment. * NEO Five-Factor Inventory (NEO-FFI): Personality assessment tool to measure the personality domains of Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness. * The McGill Pain Questionnaire - Short Form 2 (SF-MPQ-2): A self-reporting measure of pain used to assess quality and intensity of pain qualitatively. This version includes neuropathic and non-neuropathic pain conditions with a total of 22 items, with response options of 0-10, with 0 being no pain, and 10 being the worst imaginable pain. * Numerical Pain Scale (NRS): A simple used to assess pain intensity where the subject rates their pain on a scale of 0 to 10, 10 being the worst possible pain. * Visual Analog Scale (VAS): A tool used to assess pain intensity, with a line with one end labeled 0 (no pain) and 100 (worst pain possible) and subjects place the curser where they would rate their current pain intensity. The curser is not labeled with a number as it is moved. There will also be one for depression (no depression symptoms to worst depression imaginable). * Beck Anxiety Inventory (BAI): A self-report questionnaire that assesses the severity and frequency of anxiety symptoms. It is a 21-item questionnaire with answer options going 0-3, with 0 being no effect on the individual and 3 being severely bothersome. * Childhood \& Recent Traumatic Events Scale (CTES): A psychological tool to measures past and recent trauma. The childhood portion focuses on trauma that occurred before the age of 17. The recent events portion assesses trauma that occurred in the last 3 years. They both ask about death of a family member, sexual trauma, violence, and severe illness/injury. Additionally, the childhood portion asks about parental separation, while the recent events portion asks about spousal separation. * Modified Antidepressant Treatment History Form (ATHF): A widely used instrument that provides objective criteria to make an assessment if an antidepressant treatment was a failed trial or adequate trial, helping to confirm treatment resistant depression. The investigators will also be asking about previous psychotherapy treatments.

The trial acceptability and ketamine experience will be assessed using the questionnaires below:

* Mystical Experiences Questionnaire: A questionnaire that is comprised of 30 items and provides systematic and empirical methods of assessing feelings of unity, transcendence, and altered states of consciousness after taking a psychedelic. It was originally designed for psilocybin treatments; therefore, the questionnaire will have the word "psilocybin" replaced by "ketamine" to better fit this study. * Clinician Administered Dissociative States Scales (CADSS-6): Short form version of CADSS, with only 6 items. It is designed to measure dissociative symptoms, and it has been utilized by many clinical trials featuring ketamine. * Ketamine Side Effect Tool (KSET): A form that is used clinically and in research to assess side effects that occur with ketamine treatment. * NIH Stroke Scale Neurological Assessment Flow Sheet: A set of neurological checks to assess patient level of consciousness and alertness. * Likert Scale for Acceptability: A measure of acceptability for the study. It will be used as a feedback form and to help measure feasibility for the study.

• Mean Change in Numerical Pain Rating Scale Score [Time frame: Baseline, once a day for up to 7 days after baseline, within 90 minutes after ketamine dosing session, once a day for up to 7 days after ketamine dosing session, once a day up to 7 days before 2-month follow-up, and at 2-month follow-up]
• Mean Change in NEO Five-Factor Inventory-3 (NEO-FFI-3) Openness Subscale Score [Time frame: Baseline and 2-month follow-up.]
• Mean Acceptability Rating of Ketamine-Assisted Psychotherapy [Time frame: At 2 month follow-up]
• Proportion of Participants Reporting Adverse Events (AEs) [Time frame: Throughout the 8-week study.]