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Not yet recruiting NCT07245199

Protein Intake Distribution to Support Muscle Anabolism in Healthy Young Adults

No phase Interventional No Condition, Healthy Individuals

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: protein intake, protein intake, Protein intake.
Who it may be relevant to
Registry conditions: No Condition, Healthy Individuals. Basic parameters: 18 years — 40 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Netherlands
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

The purpose of the study is to evaluate whether the distribution pattern of daily protein intake affects how much muscle protein can be built in the muscle after resistance exercise and at rest.

Interventions

  • Dietary supplement protein intake
    1x 100g
  • Dietary supplement protein intake
    4x 25 g
  • Dietary supplement Protein intake
    15x 7 g

Primary outcome measures

  • fractional synthetic rate [Time frame: 24 hours]

Eligibility criteria

Inclusion criteria

  • Aged between 18-40 years
  • Healthy
  • 18.5 ≤ BMI 30 ≤ kg・m-2

Exclusion criteria

  • Smoking
  • Sports/exercise >4 sessions/week or a structured resistance or endurance training schedule
  • Lactose intolerant or allergies to milk protein
  • A history of neuromuscular problems
  • Use of anticoagulation medication
  • Individuals on any medications known to affect protein metabolism (i.e. , non-steroidal anti-inflammatories, or prescription acne medications).
  • Strict vegetarian
  • Injury or condition that would limit the participant from performing the resistance exercise.
  • Pregnancy
  • Hormone replacement therapy
  • Blood donation within the past 2 months

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Other

Study locations

Netherlands · 1 center
  • Maastricht University — Maastricht

Publications

  • Mamerow MM, Mettler JA, English KL, Casperson SL, Arentson-Lantz E, Sheffield-Moore M, Layman DK, Paddon-Jones D. Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults. J Nutr. 2014 Jun;144(6):876-80. doi: 10.3945/jn.113.185280. Epub 2014 Jan 29. PMID 24477298
  • Areta JL, Burke LM, Ross ML, Camera DM, West DW, Broad EM, Jeacocke NA, Moore DR, Stellingwerff T, Phillips SM, Hawley JA, Coffey VG. Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis. J Physiol. 2013 May 1;591(9):2319-31. doi: 10.1113/jphysiol.2012.244897. Epub 2013 Mar 4. PMID 23459753

Identifiers

NCT: NCT07245199 · NL-010056 / METC25-038 · NL-010056 / METC25-038

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗