Non-invasive Characterisation of Oral Carcinomas in Patients With Fanconi Anaemia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Oral brushing.
- Who it may be relevant to
- Registry conditions: Fanconi Anaemia. Basic parameters: from 15 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Patients with Fanconi anaemia have an increased risk of developing squamous cell carcinoma of the head and neck. In addition, their genetic vulnerability limits the use of genotoxic treatments such as radiotherapy and chemotherapy, due to increased exposure to severe toxicities. Less invasive diagnostic techniques, such as brush biopsies, which rely on cytological and ploidy analysis, offer the possibility of more systematic, comprehensive and less painful oral mapping, thereby facilitating earlier diagnosis.
Detailed description
The aim of the study is to investigate the capabilities of oral brushing for the characterisation of oral lesions in patients with Fanconi anaemia.
Interventions
- Other Oral brushing
oral brushing of all oral lesions
Primary outcome measures
- Oral brushing [Time frame: Day 0]
Secondary outcome measures (1)
- oral lesion biopsy [Time frame: Day 0]
Eligibility criteria
Inclusion criteria
- have Fanconi anaemia
- are aged 15 years or older
- have at least one oral lesion with or without warning signs
- who agree to participate in the study
Exclusion criteria
- pregnant and breastfeeding women
- protected by law (guardianship, curatorship, judicial protection)
- refusing to participate in the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07242261 · 2025_RIPH_04_Fanc-Oral