DEXDES Trial: Dexmedetomidine-Desflurane Combination in Laparoscopic Colectomy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Dexmedetomidine + Desflurane, Desflurane + Normal Saline.
- Who it may be relevant to
- Registry conditions: Colorectal Neoplasms. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Vietnam
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Efficacy and Safety of Dexmedetomidine Combined With Desflurane in Laparoscopic Colectomy: A Randomized Double-Blind Controlled Clinical Trial (DEXDES Trial)
Overview
This randomized double-blind controlled clinical trial aims to evaluate the efficacy and safety of combining Dexmedetomidine with Desflurane in patients undergoing elective laparoscopic colectomy. The study will assess whether the combination can reduce Desflurane consumption, improve intraoperative hemodynamic stability, and enhance postoperative recovery compared to Desflurane alone.
Detailed description
Dexmedetomidine, a selective alpha-2 adrenergic agonist, has sedative and analgesic properties without significant respiratory depression. Desflurane, a volatile anesthetic with low blood-gas solubility, allows rapid induction and emergence. Combining these two agents may provide anesthetic-sparing effects and promote faster postoperative recovery under ERAS protocols. This study will enroll 40 adult patients undergoing elective laparoscopic colectomy at Tam Anh General Hospital, Vietnam. Participants will be randomized into two groups: Dexmedetomidine + Desflurane versus Desflurane alone. The primary outcome is average Desflurane consumption per hour, with secondary outcomes including hemodynamic parameters, Fentanyl use, emergence quality, and incidence of postoperative nausea and vomiting.
Interventions
- Drug Dexmedetomidine + Desflurane
Dexmedetomidine bolus 1 µg/kg IV over 15 minutes before induction, followed by continuous infusion 0.5 µg/kg/h during surgery. Desflurane administered at 1 MAC with EtControl mode. - Drug Desflurane + Normal Saline
Normal saline infusion with identical timing and volume as the intervention group. Desflurane administered at 1 MAC with EtControl mode.
Primary outcome measures
- Average Desflurane consumption per hour (mL/h) during surgery. [Time frame: During surgery]
Eligibility criteria
Inclusion criteria
- Age 18-65 years
- ASA Physical Status I-II
- Elective laparoscopic colectomy
- Written informed consent provided
Exclusion criteria
- Severe cardiac, hepatic, or renal disease
- COPD or bronchial asthma
- Chronic opioid or psychotropic medication use
- Atrioventricular block (grade II-III), sick sinus syndrome
- Significant intraoperative bleeding or hemodynamic instability
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Vietnam · 1 center
- Tam Anh TP. Ho Chi Minh General Hospital — Ho Chi Minh City
Identifiers
NCT: NCT07239479 · TA2.25.11