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Not yet recruiting NCT07239401

Feasibility and Efficacy Trial of a Culturally Adapted Guided Self-Help CBT Manual for OCD

No phase Interventional Obsessive - Compulsive Disorder

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Culturally adapted Guided Self-Help OCD Manual.
Who it may be relevant to
Registry conditions: Obsessive - Compulsive Disorder. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Feasibility and Efficacy Trial of a Culturally Adapted Guided Self-Help CBT Manual for Obsessive-Compulsive Disorder: A Randomised Controlled Study From Pakistan

Overview

This randomised controlled trial (RCT) aims to assess the feasibility, acceptability, and preliminary efficacy of a culturally adapted, guided self-help cognitive behaviour therapy (CBT) manual specifically designed for individuals with OCD in Pakistan.

Detailed description

Obsessive-Compulsive Disorder (OCD) is a chronic and debilitating mental health condition characterised by persistent, intrusive thoughts (obsessions) and repetitive behaviours or mental acts (compulsions). These symptoms are often distressing, time-consuming, and cause significant functional impairment and reduction in quality of life. Cognitive and behavioural therapies, particularly the Exposure and Response Prevention (ERP), have consistently demonstrated efficacy as a first-line treatment for OCD. However, access to trained therapists remains limited in low- and middle-income countries (LMICs), including Pakistan.

Self-help interventions rooted in CBT principles, especially when culturally adapted, represent a promising, scalable, and cost-effective alternative to conventional therapy. Previous research in Pakistan has shown the feasibility and acceptability of culturally adapted CBT (CaCBT) in treating depression and OCD within primary care and outpatient settings (Naeem et al., 2011; Aslam et al., 2015).

This randomised controlled trial (RCT) aims to assess the feasibility, acceptability, and preliminary efficacy of a culturally adapted, guided self-help CBT manual specifically designed for individuals with OCD in Pakistan.

Interventions

  • Other Culturally adapted Guided Self-Help OCD Manual
    Participants will receive a culturally adapted guided self-help OCD manual based on culturally adapted CBT principles, designed to be used over ten weeks. The manual includes: Psychoeducation, Exposure and Response Prevention (ERP), Thought distraction techniques, Mood tracking and thought diaries, Identifying and modifying cognitive distortions, Problem-solving and communication strategies, and Relaxation and well-being exercises. Participants will receive the self-help manual at the time of in

Primary outcome measures

  • Obsessive-compulsive symptoms [Time frame: 12 weeks]
  • Feasibility and acceptability [Time frame: 12 weeks]
  • Clients' satisfaction [Time frame: 12 weeks]
Secondary outcome measures (2)
  • Anxiety & depression [Time frame: 12 weeks]
  • Functionality [Time frame: 12 weeks]

Eligibility criteria

Inclusion criteria

  • Age ≥ 18 years
  • Clinical diagnosis of OCD (with or without comorbid depression)
  • Minimum 5 years of formal education
  • Residing within commuting distance of the participating sites
  • Ability to read and write Urdu
  • Provision of informed written consent

Exclusion criteria

  • Current substance use or dependence (diagnosed)
  • Significant cognitive impairment (e.g., dementia or intellectual disability)
  • OCD with active psychosis

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07239401 · RCT_G_OCD_2025

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗