Retrospective Pathology Foundation Models
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Pancancer. Basic parameters: 18 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Development and Clinical Application of Deep Learning-Based Retrospective Pathology Foundation Models
Overview
By integrating retrospective multimodal data such as pathology and imaging, AI technologies offer novel solutions for disease classification, tumor grading, histological and molecular subtyping, selection of chemotherapy regimens, risk stratification, and treatment-response prediction. This research direction not only deepens our understanding of tumor biological characteristics but also provides essential support for precision medicine and individualized therapy. It holds significant theoretical and practical value and has important implications for mitigating strained medical resources and improving the accuracy of therapeutic decision-making, representing a cutting-edge application with substantial translational potential.
Primary outcome measures
- Area under ROC curve (AUC) [Time frame: Diagnostic evaluation will be performed within 1 week when the WSIs are obtained]
Secondary outcome measures (2)
- Specificity [Time frame: Diagnostic evaluation will be performed within 1 week when the WSIs are obtained]
- Sensitivity [Time frame: Diagnostic evaluation will be performed within 1 week when the WSIs are obtained]
Eligibility criteria
Inclusion criteria
- Aged 18-75 years old.
- Patients with complete pathological slides and clinical information.
Exclusion criteria
1.Patients with missing data or specimens not meeting quality control requirements for analysis.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 2 centers
- Nanfang Hospital, Southern Medical University — Guangzhou
- Qianfoshan Hospital — Jinan
Identifiers
NCT: NCT07239297 · NFEC-2025-419