Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Doppler-guided early mobilization.
- Who it may be relevant to
- Registry conditions: Arterial Ischemic Stroke. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Portugal
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke - a Randomized Clinical Trial
Overview
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability. In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.
Detailed description
Cerebrovascular diseases are the leading cause of death in Portugal and one of the most significant contributors to morbidity and disability.
Early mobilization after stroke is debated due to its potential benefits-such as fewer systemic complications and faster rehabilitation-and risks, particularly in patients with hemodynamic instability.
International guidelines support for early mobilization tailored to the patient's neurological status; however, the scientific evidence remains limited, resulting in heterogeneous practices across institutions.
Previous studies have highlighted the insufficient consideration of hemodynamic status when determining the timing of initial mobilization.
This study is a phase 3, pragmatic, prospective, multicenter randomized controlled trial with blinded outcome assessment (PROBE design: Prospective, Randomized, Open-label, Blinded Outcome Assessment), with an anticipated total duration of 36 months.
The study will be conducted in the Neurology Departments of the participating hospital centers and aims to: (1) evaluate the superiority of early mobilization guided by hemodynamic assessment following acute ischemic stroke, compared to standard clinical practice; (2) assess neurological deficits, quality of life, and cognitive function at three months, as well as hospital length of stay, blood pressure profile evolution, patient-reported outcome measures (PROMs), and employability; (3) compare adverse events between patients undergoing Doppler-guided early mobilization and those in the control group, including hospital-acquired infections, neurological deterioration, hemorrhagic transformation, and mortality.
Patients randomized to the intervention group will be mobilized according to carotid and transcranial Doppler ultrasound findings. In the presence of hemodynamic impairment, patients will undergo progressive mobilization, aiming to be out of bed by days 5 to 7 post-stroke, with gait training as neurologically feasible. In the absence of such findings, patients will begin mobilization immediately after the examination, with the goal of being out of bed and seated within 48 hours, including gait training when possible. Functional status at three months will be assessed using the modified Rankin Scale (mRS), which constitutes the study's primary endpoint.
All data collection procedures will follow formal and ethical research standards, ensuring that all informed participants voluntarily, anonymously, consent to take part in the study, with confidentiality maintained and no costs or harm to participants.
Interventions
- Procedure Doppler-guided early mobilization
Individualized early mobilization after ischemic stroke, guided by hemodynamic assessment using carotid and transcranial Doppler ultrasound. The type and timing of mobilization are adjusted according to the presence of significant hemodynamic alterations.
Primary outcome measures
- Functional status at 3 months after ischemic stroke [Time frame: 3 months post-stroke]
Secondary outcome measures (12)
- Neurological Assessment (NIHSS Scale) [Time frame: Day 0, 48 hours, Day 7 and Month 3]
- Development of hospital-acquired infections [Time frame: Up to 7 days]
- Vital signs - Body temperature [Time frame: Day 0, 48 hours, Day 7]
- Vital signs - Systolic and diastolic blood pressure [Time frame: Day 0, 48 hours, Day 7]
- Vital signs - Heart rate [Time frame: Day 0, 48 hours, Day 7]
- Mortality [Time frame: 3 months]
- EQ-5D-5L [Time frame: 3 months]
- Recurrent stroke assessment [Time frame: Day 0, 48 hours, Day 7]
- MONTREAL COGNITIVE ASSESSMENT (MoCA) [Time frame: Month 3]
- Hospital Anxiety and Depression Scale (HADS) [Time frame: 3 months]
- Mobility assessment [Time frame: 48 hours, Day 7, Month 3.]
- Breath Holding Index (BHI) - measure 1 [Time frame: Before 48 hours or Day 7 (if not performed previously)]
Eligibility criteria
Inclusion criteria
- Patients diagnosed with ischemic stroke aged 18 years or older;
- Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours;
- Informed consent obtained from the patient or legal representative.
Exclusion criteria
- Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4;
- Diagnosis of Transient Ischemic Attack (TIA);
- Severe hemodynamic instability, defined as:
- Systolic blood pressure < 100 mmHg or > 220 mmHg;
- Peripheral oxygen saturation < 92%;
- Heart rate < 40 or > 112 beats per minute;
- Body temperature > 38.5°C;
- Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale < 10);
- Patients who underwent neurosurgical intervention within the past 30 days;
- Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer);
- Requirement for continuous monitoring or continuous intravenous drug infusion;
- Acute deep vein thrombosis/pulmonary embolism.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Prevention
Study locations
Portugal · 3 centers
- Unidade Local de Saude de Coimbra — Coimbra
- Unidade Local de Saúde de Santa Maria — Lisbon
- Unidade Local de Saúde de São João — Porto
Identifiers
NCT: NCT07232498 · 197/24 CE