Detection of Microplastics in Patients With Periodontitis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Periodontal Diseases, Periodontitis. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Detection of Microplastics in Patients With Periodontitis - a Cross-sectional Study
Overview
Plastic particles known as microplastics are now a ubiquitous part of the environment. Human exposure to microplastics occurs through the consumption of contaminated food and polluted air, which affect the intestinal system. Several studies have detected the presence of microplastics in various parts of the human digestive system, e.g., in feces. Unfortunately, little is known about the presence of microplastics in the mouth as the primary part of the digestive system. Periodontal pockets can be considered an ideal deposition site for microplastics. Since microplastics are suspected of being an immunomodulatory factor, there is great interest in their presence in subgingival plaque and their possible exacerbation of chronic inflammatory diseases such as periodontitis. The following study aims to clarify the presence, classification, and concentration of microplastics in subgingival plaque. No comparable study has been identified to date.
Primary outcome measures
- Microplastics [Time frame: one year]
Eligibility criteria
Inclusion criteria
- Adults aged 18 and over
- Gender: Female / male / diverse
- Patients
- who have been diagnosed with stage III and IV periodontitis.
- who have not yet started periodontal treatment.
- who still have at least 20 teeth. Providing written consent to participate in the study.
Exclusion criteria
- Patients
- who have already been treated for periodontitis
- who have already undergone/begun periodontitis treatment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Francis DL, Pape Reddy SS. Microplastics in the Pathogenesis of Periodontal Diseases: A Narrative Review. Ann Glob Health. 2025 Oct 3;91(1):69. doi: 10.5334/aogh.4861. eCollection 2025. PMID 41079032
Identifiers
NCT: NCT07231198 · 17538733 · SFU