Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Questionnaire.
- Who it may be relevant to
- Registry conditions: Thyroid Nodules, Pulsed Field Ablation. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
Detailed description
Primary Objectives
• To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care
Secondary Objectives
* To determine changes in health-related quality of life changes following ultrasound-guided nsPFA * To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA. * To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.
Interventions
- Other Questionnaire
patient-reported outcomes questionnaire
Primary outcome measures
- Quality-of-life Questionnaire [Time frame: Through study completion; an average of 1 year]
Eligibility criteria
Eligibility Criteria
- Scheduled to undergo ultrasound guided nsPFA as standard of care
- Age 18 to 80 years.
- Capable of providing independent consent.
- Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:
- Benign FNA X 2 or
- Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
- Benign FNA X 1 and radiographic/laboratory evidence of functional nature
- Nodule measuring >2cm in greatest dimension
- Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
- No abnormal cervical lymph nodes during screening visit .
Exclusion criteria
- Age <18
- Patients considered unsuitable for nsPFA by the treating physician
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- MD Anderson Cancer Center — Houston
Identifiers
NCT: NCT07226804 · 2025-0483 · NCI-2025-08362