Clinical Trial Protocol: Alzheimer's Dementia Underlying Encephalopathy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Quest AD-Detect blood test.
- Who it may be relevant to
- Registry conditions: Alzheimer Dementia, Alzheimer Disease, Delirium Confusional State, Encephalopathy. Basic parameters: 60 years — 90 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The goal of this clinical trial is to determine if utilizing the Quest AD-Detect blood test, while patient's are hospitalized for a cognitive diagnosis (such as delirium or encephalopathy), will result in an earlier diagnosis of underlying Alzheimer's disease. * Will this blood test have the ability to distinguish between Alzheimer's disease and other causes of cognitive impairment in the inpatient setting? * Neurology Clinic will complete a 6-month post-hospitalization follow up with patients who have had the Quest AD-Detect Alzheimer's Disease blood test completed while they were inpatient to discuss the risk assessment portfolio
Interventions
- Diagnostic test Quest AD-Detect blood test
Blood will be collected and sent for testing using the Quest AD-Detect blood test
Primary outcome measures
- To show the percentage of patients (21 patients in the study) who presented with a cognitive diagnosis (including but not limited to delirium, encephalopathy, etc.) that have a positive biomarker for Alzheimer's dementia [Time frame: From enrollment to 6 month follow up appointment with Neurology Clinic.]
Eligibility criteria
Inclusion criteria
- Ages 60 to 90 years old
- No prior diagnosis of dementia
- Currently hospitalized with cognitive diagnosis, including but no limited to; delirium, encephalopathy, etc. thought to be secondary to a toxic/metabolic state
Exclusion criteria
- Age under 60 years
- Prior diagnosis of dementing illness or other organic etiology to cognitive impairment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
United States · 6 centers
- Cumberland Medical Center — Crossville
- Roane Medical Center — Harriman
- Fort Sanders Regional Medical Center — Knoxville
- Fort Loudon Medical Center — Lenoir City
- Methodist Medical Center — Oak Ridge
- LeConte Medical Center — Sevierville
Identifiers
NCT: NCT07222280 · ADUE2025