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Recruiting NCT07220655

Cognition and Ultrasound

No phase Interventional Healthy Participants

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Low-Intensity Focused Ultrasound (FUS or LIFU).
Who it may be relevant to
Registry conditions: Healthy Participants. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

Our primary goal is to investigate the role of Low-Intensity Focused Ultrasound (LIFU) neuromodulation on deep brain targets, and its potential to improve cognition

Interventions

  • Device Low-Intensity Focused Ultrasound (FUS or LIFU)
    We will use an established, currently-marketed device to deliver LIFU neuromodulation.

Primary outcome measures

  • Deep Brain Targets Reached [Time frame: Hour 1]
  • Multi-Source Interference Test (MSIT) Performance [Time frame: Hour 1]
  • 28/Posit Science Performance [Time frame: Hour 1]

Eligibility criteria

Inclusion criteria

  • 18 years of age or older
  • Speak English (as assessed by their ability to read/answer survey questions)
  • May be required to score in the appropriate range on self-report measures

Exclusion criteria

  • They have a neurological disorder which may impact their fMRI scan or cause their reaction to LIFU to differ from that of healthy adults.
  • They take any psychoactive medication.
  • They are unable to undergo fMRI scanning due to a contraindication such as claustrophobia, unremovable piercings, pregnancy, the presence of medical devices such as pacemakers, or a movement or sleep disorder.
  • Are pregnant, or may have reason to believe that they are pregnant.
  • They have a diagnosis of a psychiatric condition other than depression or anxiety

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Other

Study locations

United States · 1 center
  • University of Minnesota — Minneapolis

Identifiers

NCT: NCT07220655 · PSYCH-2024-33067

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗