Effects of a 5-Week Probiotic Supplementation Intervention on Markers of Delayed Onset Muscle Soreness
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Lactobacillus casei, Placebo Capsule(s).
- Who it may be relevant to
- Registry conditions: Exercise Induced Muscle Damage, Delayed Onset Muscle Soreness (DOMS). Basic parameters: 18 years — 30 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of this study is to evaluate how probiotic supplementation (PS) influences post-exercise recovery in healthy, physically active young adults. Researchers aim to determine if the Lactobacillus casei probiotic strain reduces symptoms of delayed onset muscle soreness (DOMS) based on perceived muscle soreness, pressure pain threshold, and power output following exercise induced muscle damage (EIMD).
Interventions
- Dietary supplement Lactobacillus casei
Probiohealth is the manufacturer of this strain and they use a stringent quality control program that utilizes a multi point product variability check system. - Other Placebo Capsule(s)
The brand name of placebo capsules that will be used in this study is Magic Bullet Placebo Capsules. This placebo is manufactured by Progressive Placebo as stated on the product label.
Primary outcome measures
- Change in perceived muscle soreness [Time frame: From baseline to post 5-week intervention]
- Change in pressure pain threshold (PPT) [Time frame: From baseline to post 5-week intervention]
- Change in countermovement jump assessment (CMJ) performance recovery [Time frame: From baseline to post 5-week intervention]
Eligibility criteria
Inclusion criteria
- complete a minimum of 150 minutes a week of at least moderate intensity exercise in either an endurance-based or resistance-based training style based on a self-reported physical activity over the past month
- good general health with no injuries or health conditions that would affect physical activity
- willing to abstain from consistent NSAID use and other probiotic supplements over the course of this study
Exclusion criteria
- known musculoskeletal injuries or physical limitations that could interfere with performing the designated physical activity required
- underlying conditions that could place them at an increased risk during exercise such as cardiovascular, respiratory, or metabolic diseases
- currently take a probiotic supplement, are prescribed and taking an antibiotic during the intervention, or report using NSAIDs or steroids within the recovery time window
- report using an NSAID more than twice a week on a regular basis
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Quadruple blind
- Primary purpose
- Prevention
Study locations
United States · 1 center
- University of Minnesota — Minneapolis
Identifiers
NCT: NCT07219498 · Probiotic Supplementation