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Recruiting NCT07211321

Linking Diet, Inflammation, Gut Microbiota, and Sarcopenia: A Cross-Sectional Study

— Observational Sarcopenia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: No Intervention: Observational Cohort.
Who it may be relevant to
Registry conditions: Sarcopenia. Basic parameters: from 60 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Exploring the Relationship of Diets Inflammatory, Gut Microbiota, and Sarcopenia: A Cross-Sectional Study

Overview

Based on the analysis of dietary characteristics, gut microbiota diversity, and composition, this study investigates the relationships between the dietary inflammatory potential, gut microbiota, and sarcopenia. Furthermore, it explores the mediating role of gut microbiota in the association between the dietary inflammatory index and the risk of sarcopenia. The findings are expected to provide insights into the mechanisms through which dietary inflammation influences the development and progression of sarcopenia, and to offer a basis for dietary and nutritional interventions aimed at preventing or managing this condition.

Interventions

  • Other No Intervention: Observational Cohort
    No Intervention

Primary outcome measures

  • The prevalence of sarcopenia [Time frame: Through study completion, an average of 1 year]
  • Change in absolute abundance of Faecalibacterium prausnitzii [Time frame: Through study completion, an average of 1 year]
  • Dietary Characteristics [Time frame: Through study completion, an average of 1 year]

Eligibility criteria

Inclusion criteria

  • Permanent residents of the community aged 60 years or older.
  • Continuous residence duration in the community for more than 5 years.

Exclusion criteria

  • Taking medications known to affect muscle function (e.g., corticosteroids, protein supplements, muscle enhancers).
  • Requiring walking assistance or having severe cognitive impairment that would preclude successful completion of assessments including bioelectrical impedance analysis (BIA), gait speed measurement, and handgrip strength testing.
  • Presence of a cardiac pacemaker, which contraindicates BIA measurement.
  • Diagnosis of one or more chronic diseases that significantly limit dietary intake.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Case-control

Study locations

China · 1 center
  • Lanzhou university — Lanzhou

Identifiers

NCT: NCT07211321 · IRB23070101 · No. 23JRRA1064

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗