Physical Exercise in Patients With First Psychotic Episode
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Other: Strength physical exercise programme, Other: Normal life.
- Who it may be relevant to
- Registry conditions: Telomere Length, Exercise, First Episode Psychosis (FEP). Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Impact of Physical Exercise on Telomere Length and Other Markers of Premature Ageing in First-episode Psychosis.
Overview
Justification: Patients with first-episode psychosis are at increased risk of premature ageing and early mortality, associated with telomere shortening and increased inflammatory markers. Physical exercise has shown protective effects in the general population, but there are no intervention studies in this population. Objective: To evaluate the effect of a strength training programme on telomere length and other markers of cellular ageing in people with a first episode of psychosis. Material and methods: Quasi-experimental study with patients aged 18-35 years included in the PRINT programme (Salamanca). Standard treatment will be compared with standard treatment plus a 12-week strength training programme. Telomere length (qPCR), inflammatory and senescence markers (proteomics), body composition, frailty and quality of life will be analysed. Applicability: The results could support the inclusion of physical exercise programmes as a complementary intervention in early psychosis care, promoting overall health, quality of life and reducing the gap in life expectancy compared to the general population.
Interventions
- Other Other: Strength physical exercise programme
12 multi-joint strength exercises will be developed. Participants will be taught the rating scale of perceived exertion (RPE) based on the number of repetitions in reserve (RIR). Participants will be asked that during the performance of each of the exercises they must perceive an effort between 7-8 within the overall score of the scale (0-10; 0 = no effort at all and 10 = cannot perform one more repetition, i.e. maximal effort). When subjects perform the 12 repetitions with lower perceived exert - Other Other: Normal life
Description: Normal life and carry out all the activities they have been doing previously.
Primary outcome measures
- Telomere Length [Time frame: Baseline and immediately after the intervention]
Secondary outcome measures (3)
- Fragility [Time frame: Baseline and immediately after the intervention]
- Quality of life [Time frame: Baseline and immediately after the intervention]
- Differential plasma profile [Time frame: Baseline and immediately after the intervention]
Eligibility criteria
Inclusion criteria
- be at least 18 years of age
- Having experienced a first psychotic episode in the last 3 years
Exclusion criteria
- are unable to read and understand the patient information sheet and sign the informed consent form.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Health services research
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07207538 · ExerciseFirstPsychoticEpisode