Enrolling by invitation NCT07203638
Efficacy and Safety of Prophylactic Antibiotics in Preventing Ventilator-associated Pneumonia: A Randomized, Double Blind, Placebo-controlled Trial
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Beta Lactam Antibiotics, Salin.
- Who it may be relevant to
- Registry conditions: Ventilator-Associated Pneumonia (VAP). Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Evaluate efficacy and safety of prophylactic antibiotics in preventing early ventilator-associated pneumonia
Interventions
- Drug Beta Lactam Antibiotics
Beta lactam cefipim infusion (20mg/kg -12h -2 days ) total volume 10 ml - Drug Salin
Patient will receive .9 % saline (10ml /12h/2days)
Primary outcome measures
- Ventilation associated pneumonia [Time frame: from the 2nd to the 7th day of mechanical ventilation]
Eligibility criteria
Inclusion criteria
- • Age > 18 years or older
- Both sexes will be included.
- Invasive mechanical ventilation
Exclusion criteria
- ongoing pneumonia or gross aspiration confirmed by the presence of lung infiltrates on chest radiographs at admission before invasive ventilation
- previous lung disease precluding accurate interpretation of chest radiographs
- ongoing antibiotic therapy or during the week before admission
- known chronic colonization with multidrug-resistant bacteria
- known allergy to beta-lactam antibiotics
- Pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Benha university hospital — Banhā
Identifiers
NCT: NCT07203638 · MD 1-11-2024